Nov 2, 2021 · 光遗传激活LC→BLA投射能够显著增加BLA内去甲肾上腺素的水平，同时小鼠的焦虑样行为也显著增加。 该研究还发现激活LC→BLA投射后BLA神经元的c‑Fos表达水平增加，并且这种c‑Fos表达水平增加更多出现在BLA中投射至vHPC及CeA的神经元中 。

Dec 29, 2022 · Neuronal subpopulations distributed throughout the brain generate and maintain wakefulness. Output from the PBN, LC, TMN, LH and BF modulates thalamocortical and cortical circuits and promotes...

臂旁核 （Parabrachial Nucleus， PBN），是位于脑桥至关重要的行为调控核团，参与调节呼吸、情绪、睡眠、痛觉传递和摄食等多种行为和生理活动。

Nov 1, 2022 · The parabrachial nucleus (PBN), located at the junction of the midbrain and pons, relays sensory information from the periphery primarily to the forebrain, thereby playing a major role in informing the brain of both the internal state (interoception) and external conditions (exteroception) to facilitate responses to adverse conditions and help ...

Nerve circuits related to anxiety include ventral tegmental area → central amygdala (VTA→CeA DA), locus coeruleus → basolateral amygdala (LC NE →BLA). The neural circuit related to pain aversion...

摘要: 臂旁核 (parabrachial nucleus, PB)是环绕在脑桥结合臂周围的灰质结构，主要由谷氨酸、γ-氨基丁酸 (γ-aminobutyric acid, GABA)和脑啡肽神经元组成。 PB与下丘脑、基底前脑等觉醒核团有着广泛的神经纤维联系，特异性损毁PB可引起动物昏迷样症状。 同时，PB向非快动眼 (non-rapid eye movement，NREM)睡眠核团腹内侧视前区投射，并接受来自面旁核的投射，激活面旁核中的GABA能神经元可促进NREM睡眠，表明PB可能参与NREM睡眠的调控。 此外，快动眼 (rapid …

Mar 3, 2021 · Yang and colleagues provided strong evidence for co-transmission in LC neurons projecting to the PBN by optogenetically activating noradrenergic neurons, which produced a post-synaptic current in PBN neurons that was also sensitive to glutamate antagonism.

Aug 21, 2024 · Chemogenetic activation of glutamatergic PBN neurons reduces sevoflurane sensitivity [154, 155, 156]. The LC is an NE center and plays a pivotal role in regulating transitions between states of vigilance and arousal, with LC-NE neurons being most active during wakefulness [157].

Jan 1, 2022 · Our results elucidate the neuroanatomical organization of PVN MC4R+ circuits and shed new light on the roles of PVN MC4R+ pathways in autonomic control of thermoregulation, cardiovascular function, and biphasic behavioral activation. 1. Introduction.

臂旁核（PBN）在调节觉醒和促进全身麻醉唤醒方面发挥着至关重要的作用。 然而，PBN 投影在全身麻醉过程中的具体作用仍不清楚。 在这项研究中，我们将编码兴奋性或抑制性光遗传学探针的 AAV 相关病毒双侧注射到 PBN 中，并在 LH 或 BF 区域植入光纤。