Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the PAX9 gene. [5][6] It is also found in other mammals. [7] This gene is a member of the paired box (PAX) family of transcription factors.

2024年12月25日 · PAX9 (Paired Box 9) is a Protein Coding gene. Diseases associated with PAX9 include Tooth Agenesis, Selective, 3 and Tooth Agenesis. Among its related pathways are Endoderm differentiation and Wnt / Hedgehog / Notch.

Paired box 9 (PAX9) is a transcription factor of the PAX family functioning as both a transcriptional activator and repressor. Its functional roles in the embryonic development of various tissues and organs have been well studied. However, its roles ...

PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis. Patterns of molar agenesis associated with p.P20L and p.R77Q variants in PAX9. PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer. PAX7, PAX9 and RYK Expression in Cleft Affected Tissue.

PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme. Polymorphisms in the upstream promoter ...

2021年8月1日 · Paired box 9 (PAX9) gene belongs to the PAX family, which encodes a family of metazoan transcription factors documented by a conserved DNA binding paired domain 128-amino-acids, critically essential for physiology and development.

PAX9 is a member of the PAX gene family, specifically located in zone 3 (11p13) of the short arm of human chromosome 11. It is a transcription factor that plays a crucial role in regulating the expression of target genes during development.

2020年8月19日 · Here we reveal yet another connection between craniofacial development and making ribosomes through the protein Paired Box 9 (PAX9). PAX9 functions as an RNA Polymerase II transcription factor to regulate the expression of proteins required for craniofacial and tooth development in humans.

2019年9月23日 · We show here that Pax9-deficient mice are born with complex cardiovascular malformations that affect the outflow tract and aortic arch arteries with failure of the 3rd and 4th pharyngeal arch arteries to form correctly.

Pax9 encodes a paired-box homeodomain transcription factor and is critical for the development of multiple organs. Using CrispR/Cas9-mediated homologous directed repair (HDR), we generated a new Pax9-CreER knock-in mouse line in which the CreERT2 ...