PALB2 (partner and localizer of BRCA2) is a specific type of genetic mutation. Although PALB2 normally helps prevent cancer, when it mutates, it no longer works correctly, which means people with a PALB2 mutation have a higher risk of breast cancer.

PALB2 was recently identified as a susceptibility gene for familial pancreatic cancer by scientists at the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. This has paved for the way for developing a new gene test for families where pancreatic cancer occurs in multiple family members. [ 18 ]

2023年7月17日 · If you both have a mutation in the PALB2 gene, which is rare, there’s a chance your child could be born with a serious condition called Fanconi Anemia (FA). FA is a genetic disorder that can cause birth defects, bone marrow failure, and a risk of cancer.

2024年9月22日 · People with an inherited PALB2 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

2021年11月9日 · One of these genes has recently been receiving new attention: PALB2, a potent breast cancer susceptibility gene related to the better-known BRCA1 and BRCA2 genes. Someone who inherits a PALB2 mutation faces a 35% chance of developing breast cancer by age 70, and if she also has a strong family history of the disease, her risk is about 58% by ...

2025年2月14日 · Evidence-based, expert-reviewed summary about the PALB2 gene, the cancer risks associated with PALB2, screening, risk-reduction, treatment, and prognosis.

PALB2 functions as a tumor suppressor and participates in the maintenance of genome integrity. In this review, we summarize the current knowledge of the biological roles of the multifaceted PALB2 protein and of its regulation.

2024年9月6日 · People with an inherited mutation in PALB2 have increased risk for certain cancers, including: breast cancer (male and female) pancreatic; fallopian tube; ovarian; What can people with a PALB2 mutation do? People with a PALB2 mutation have options for screening, prevention and treatment of hereditary cancer. There are expert guidelines and ...

2021年10月7日 · But what about the PALB2 gene, which stands for Partner And Locator of BRCA2? A recent study in the New England Journal of Medicine showed women who carry a mutation in the PALB2 gene were 35% more likely to be diagnosed with breast cancer by age 70, compared with women who don't carry the mutation.

PALB2 (Partner and Localizer of BRCA2) was first identified as a BRCA2-interacting protein. Subsequently, PALB2 has been recognized as a cog in the cellular machinery for DNA repair by homologous recombination (HR).