p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in …

In the cell, p53 protein binds DNA, which in turn stimulates another gene to produce a protein called p21 that interacts with a cell division-stimulating protein (cdk2). When p21 is complexed …

The p53 protein is a transcription factor that controls the output of many biological processes according to the type of cellular stress signal input. Stress signals known to activate p53 …

Here, we discuss key structural aspects of p53 function and its inactivation by oncogenic mutations. Concerted action of folded and intrinsically disordered domains of the highly …

The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but …

p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis.

The p53 protein, encoded by the TP53 gene, functions as a transcription factor regulating genes involved in cell cycle control, DNA repair, and apoptosis. Typically low under normal …

2024年3月28日 · We learned that p53 is a DNA sequence-dependent transcription factor whose protein sequence comprises N-terminal transactivation domains and a central DNA binding …

2022年8月17日 · More than half of all cancers have mutations in a gene called p53. The protein made from this gene is what’s called a tumor suppressor: When working properly, it guards …

In recent years, the field has begun to change its focus by studying the role of the p53 protein using clinical material from patients. To reflect this change in direction, this collection brings …