其他 E2F 也已被证明参与DNA损伤反应和细胞凋亡，包括 E2F2、3、4、7、8（E2f7作为p53靶点，可以抑制细胞周期E2F靶基因的表达，加强或维持 p53 启动的细胞周期停滞）。

Deregulated E2f, which is often present in human tumours, constitutes an oncogenic stress that activates p53. Specifically, E2f indirectly affects the level and activity of p53 by...

Mar 31, 2022 · RB-E2F complexes bind to promoters of a large fraction of genes repressed by p53 and p21. The resulting p53-p21-RB signaling overlaps substantially with the related p53 …

对相关 p53-p21-DREAM 信号通路控制的 p53-p21-RB 靶标和基因的检查表明，这两组有很大的重叠。 从机制上讲，这可以通过在目标启动子的 E2F 位点用 DREAM 转录抑制复合物替换 RB …

P53 suppresses tumorigenesis by inducing cellular senescence or apoptosis. Hence, in almost all cancers, the p53 pathway is also disabled. Here we will introduce the canonical functions of …

We show that E2F1 upregulates the expression of four proapoptotic cofactors of p53--ASPP1, ASPP2, JMY and TP53INP1--through a direct transcriptional mechanism. Adenovirus E1A …

The results indicate that p53 differentially regulates the activities of two subclasses (E2F-1/-2/-3 vs. E2F-4/-5) of E2F transcription factors. Detailed analysis using a two-hybrid approach in …

Mar 17, 2005 · Many p53 targets that play a role in growth arrest or apoptosis have been identified, but given the frequent occurrence of mutations in the RB pathway and established …

However, a large body of evidence indicates that, in addition to their independent effects on cell fate, there is extensive crosstalk between these two pathways, and specifically between the …

Apr 26, 1994 · The tumor-suppressor protein p53 appears to function at the G1 phase of the cell cycle as a checkpoint in response to DNA damage. Mutations in the p53 gene lead to an …