P4HA2 Gene - GeneCards | P4HA2 Protein | P4HA2 Antibody
Dec 25, 2024 · P4HA2 (Prolyl 4-Hydroxylase Subunit Alpha 2) is a Protein Coding gene. Diseases associated with P4HA2 include Myopia 25, Autosomal Dominant and Temporal Arteritis. …
P4HA2 promotes proliferation, invasion, and metastasis through ...
Jul 1, 2024 · Our results suggest that P4HA2 overexpression is significantly associated with the progression of OSCC, whereas P4HA2 knockdown inhibits the proliferation, migration, and …
P4HA2 activates mTOR via hydroxylation and targeting P4HA2
Apr 23, 2024 · Here, we demonstrate that prolyl 4-hydroxylase alpha-2 (P4HA2) binds directly to mTOR and hydroxylates one highly conserved proline 2341 (P2341) within a kinase domain of …
P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog
Jun 22, 2024 · Our study reveals a novel regulatory mechanism involving prolyl 4-hydroxylase 2 (P4HA2), which forms a complex with KIF7 and is essential for signal transduction of Hh …
P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and ...
Through differential gene expression analysis between the microtumor models with an overlap of hypoxia, partial EMT and migration signatures, we identified prolyl 4-hydroxylase subunit 2 …
P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ (human)]
P4HA2 was identified as a novel causative gene for nonsyndromic high myopia. Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential …
P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate ...
KO of P4ha2 led to an increase in cell migration and invasion, which was reversed upon Yap1 KD. Our study identified a novel regulatory mechanism of YAP1 by which P4HA2-dependent prolyl …
P4HA2 Promotes Epithelial-to-Mesenchymal Transition and Glioma ... - PubMed
Aug 16, 2021 · Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ Homo sapiens …
Oct 28, 2024 · Title: P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer. Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts …
P4HA2 promotes tumor progression and is transcriptionally …
Jun 10, 2024 · P4HA2 has been implicated in various malignant tumors; however, its expression and functional role in colorectal cancer (CRC) remain poorly elucidated. This study aims to …
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