P4HA1 Gene - GeneCards | P4HA1 Protein | P4HA1 Antibody
Dec 25, 2024 · P4HA1 (Prolyl 4-Hydroxylase Subunit Alpha 1) is a Protein Coding gene. Diseases associated with P4HA1 include Arterial Calcification, Generalized, Of Infancy, 2 and …
肿瘤免疫 | Cancer.Cell | 靶向 P4HA1 促进 CD8+ T 细胞前体扩增， …
Feb 10, 2025 · P4HA1通过破坏 三羧酸循环 诱导 线粒体功能障碍 和T细胞耗竭; 靶向P4HA1可扩增祖细胞CD8+ T细胞，从而实现全身性抗肿瘤免疫; P4HA1+ CD8+ T细胞亚群是癌症进展和免 …
脯氨酰 4-羟化酶亚基 α 1（P4HA1）基因 - MCE-生物活性 ...
该基因编码脯氨酰 4-羟化酶的一个成分，脯氨酰 4-羟化酶是胶原蛋白合成中的一种关键酶，由两个相同的 α 亚基和两个 β 亚基组成。 编码的蛋白质是几种不同类型的 alpha 亚基之一，并提供 …
P4HA1 - Wikipedia
Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene. [5] [6] This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in …
P4HA1，一种与肺腺癌和泛癌中的免疫浸润相关的预后生物标志物 …
Feb 6, 2022 · 目的： 脯氨酰4-羟化酶α多肽i（p4ha1）是胶原合成的关键酶，由两个相同的α亚基和两个β亚基组成。然而，p4ha1 在肿瘤免疫微环境 (time) 中的免疫调节作用仍不清楚。
Targeting P4HA1 promotes CD8 - ScienceDirect
Feb 10, 2025 · Targeting P4HA1 enhances both adoptive and endogenous TCF1 + CD8 + T progenitor expansion while mitigating the development of exhaustion in the tumor, TDLN, and …
Cancer Cell：于强团队发现增强实体瘤免疫治疗效果的新靶点——P4HA1 …
在这项最新研究中，研究团队发现，编码脯氨酰-4-羟化酶1的p4ha1基因，是cd8+ t细胞分化的关键调控因子，在肿瘤引流淋巴结（tdln）和缺氧的 肿瘤微环境 中强烈上调。
Targeting P4HA1 promotes CD8 + T cell progenitor expansion …
Feb 10, 2025 · Here, we identify P4HA1, encoding prolyl 4-hydroxylase 1, as a crucial regulator of CD8 + T cell differentiation strongly upregulated in tumor-draining lymph nodes (TDLNs) and …
Cancer Cell | 于强团队揭示P4HA1脯氨酰羟化酶在CD8+ T细胞分化 …
Dec 27, 2024 · 研究发现，cd8+ t细胞中的p4ha1（脯氨酸4-羟化酶1） 在肿瘤引流淋巴结 （tdln） 和缺氧肿瘤微环境中显著上调，成为肿瘤免疫逃逸的关键分子。p4ha1蛋白积累在线粒体中， …
Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α ... - Nature
Oct 26, 2018 · Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 …
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