2024年12月25日 · P4HA1 (Prolyl 4-Hydroxylase Subunit Alpha 1) is a Protein Coding gene. Diseases associated with P4HA1 include Arterial Calcification, Generalized, Of Infancy, 2 and …

2018年10月26日 · Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 …

2025年2月10日 · Targeting P4HA1 enhances both adoptive and endogenous TCF1 + CD8 + T progenitor expansion while mitigating the development of exhaustion in the tumor, TDLN, and …

2024年12月26日 · Here, we identify P4HA1, encoding prolyl 4-hydroxylase 1, as a crucial regulator of CD8 + T cell differentiation strongly upregulated in tumor-draining lymph nodes …

P4HA1 is crucial to the proper three-dimensional folding of the newly synthesized procollagen chains. P4HA1 is also involved in the remodeling of the extracellular matrix (Gilkes et al., …

Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and two beta subunits. However, the …

2025年2月27日 · Importantly, P4HA1 undergoes alternative splicing under hypoxia, where the inclusion of exon 9a is increased. Interestingly, involvement of ATF3 in P4HA1 splicing was …

2025年2月27日 · The P4HA1 9a isoform leads to enhanced invasion under hypoxic conditions by increasing deposition of collagen in the ECM. These results reveal a novel hypoxia-induced …

Title: P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma. Identification and verification of FN1, P4HA1 and CREBBP as potential …

2021年12月13日 · Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and two beta subunits. However, …