
P2RY6 Gene - GeneCards | P2RY6 Protein | P2RY6 Antibody
2024年12月25日 · P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. Diseases associated with P2RY6 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 and Parkinson's Disease. Among its related pathways are Purinergic signaling and GPCR downstream signalling.
Immunological role and clinical prognostic significance of P2RY6 …
High expression of P2RY6 was closely associated with a poor prognosis for patients, and it plays a role in regulating immune-related pathways, such as cytokine-cytokine receptor interaction. Notably, P2RY6 expression is closely linked to the abundance of CD8 + T cells.
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate ... - Nature
2025年3月4日 · We found that inhibiting CYSLTR2/P2RY6 genetically or pharmacologically alleviated ceramide-induced atherosclerosis aggravation. Additionally, increased ceramide levels correlated with...
P2RY6 deletion promotes UVB-induced skin carcinogenesis by
2024年10月22日 · The CPD accumulation and acute inflammatory response enhanced by the loss of the P2RY6 gene can be reversed by an AKT inhibitor. These findings suggest that P2RY6 may act as a tumor suppressor in UVB-induced skin …
P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by
P2RY6 is highly expressed in skin keratinocytes, but its function in skin diseases is unclear. We use a two-step chemical induction method to induce mouse skin tumor formation. Multiple in vitro and in vivo assays were used to explore the role of P2RY6 in skin tumors.
P2RY6 pyrimidinergic receptor P2Y6 [ Homo sapiens (human) ]
2025年2月8日 · Title: Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE (2) production. Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.
P2RY6 pyrimidinergic receptor P2Y6 [ (human)] - National Center …
Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production. Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.
P2Y6 receptor-mediated signaling amplifies TLR-induced pro
2022年9月20日 · Purinergic receptors are powerful modulators of TLR-induced responses, and we here characterized the effects of P2Y6 receptor (P2RY6)-mediated signaling on TLR responses of rhesus macaque primary bone marrow-derived macrophages (BMDM) and microglia, using the selective P2RY6 antagonist MRS2578.
Tumor-intrinsic P2RY6 drives immunosuppression by ... - Cell Press
2024年7月23日 · Xu et al. identify P2RY6 as a key driver of immune evasion in cancers, promoting an immunosuppressive tumor microenvironment and resistance to immunotherapy, thus nominating P2RY6 as a precision immunotherapy target.
Nucleotide metabolism in cancer cells fuels a UDP-driven ... - Nature
2024年6月6日 · We show that CDA in cancer cells contributes to the uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y 6.
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