P2RY6 Gene - GeneCards | P2RY6 Protein | P2RY6 Antibody
2024年12月25日 · P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. Diseases associated with P2RY6 include Frontotemporal Dementia And/Or Amyotrophic Lateral …
Immunological role and clinical prognostic significance of P2RY6 …
High expression of P2RY6 was closely associated with a poor prognosis for patients, and it plays a role in regulating immune-related pathways, such as cytokine-cytokine receptor interaction. …
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate ... - Nature
2025年3月4日 · We found that inhibiting CYSLTR2/P2RY6 genetically or pharmacologically alleviated ceramide-induced atherosclerosis aggravation. Additionally, increased ceramide …
P2RY6 deletion promotes UVB-induced skin carcinogenesis by
2024年10月22日 · The CPD accumulation and acute inflammatory response enhanced by the loss of the P2RY6 gene can be reversed by an AKT inhibitor. These findings suggest that …
P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by
P2RY6 is highly expressed in skin keratinocytes, but its function in skin diseases is unclear. We use a two-step chemical induction method to induce mouse skin tumor formation. Multiple in …
P2RY6 pyrimidinergic receptor P2Y6 [ Homo sapiens (human) ]
2025年2月8日 · Title: Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE (2) production. Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA …
P2RY6 pyrimidinergic receptor P2Y6 [ (human)] - National Center …
Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production. Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the …
P2Y6 receptor-mediated signaling amplifies TLR-induced pro
2022年9月20日 · Purinergic receptors are powerful modulators of TLR-induced responses, and we here characterized the effects of P2Y6 receptor (P2RY6)-mediated signaling on TLR …
Tumor-intrinsic P2RY6 drives immunosuppression by ... - Cell Press
2024年7月23日 · Xu et al. identify P2RY6 as a key driver of immune evasion in cancers, promoting an immunosuppressive tumor microenvironment and resistance to immunotherapy, …
Nucleotide metabolism in cancer cells fuels a UDP-driven ... - Nature
2024年6月6日 · We show that CDA in cancer cells contributes to the uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) …
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