OSW-1, isolated from Ornithogalum caudatum, is a specific antagonist of osterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) with GI50s in the nanomolar range in human cancer lines. OSBP/ORP4 [1]. OSW-1 对结肠癌细胞有很强的抑制作用，对正常细胞的细胞毒性较低。 OSW-1 对 SW480 和 LoVo 结肠癌细胞的抗增殖作用通过使用 CCK8 测定法测量细胞活力来表征，并将结果与其他临床抗癌剂进行比较。

Sep 23, 2021 · In this regards, OSW-1, which was isolated from the bulbs of Ornithogalum saundersiae in 1992, has exhibited powerful anticancer activities in various cancers. However, after almost three decades, OSW-1 is still far from becoming a real anticancer agent for its anticancer mechanisms remain unclear.

Dec 7, 2005 · Using various human cancer and nonmalignant cell lines, we investigated the anticancer activity and selectivity of OSW-1 and its underlying mechanisms of action. OSW-1 exhibited extremely potent cytotoxic activity against cancer cells in vitro.

Sep 22, 2021 · In 1992, Kubo S et al. (9) isolated OSW-1, a steroidal saponins, from the bulbs of O. saundersiae, which has a high cytotoxicity to cancer cells. Its anticancer effect is about 10-100 times that of many chemotherapeutic drugs commonly used in clinic, such as doxorubicin, camptothecin and paclitaxel (10).

Jul 15, 2019 · OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive.

OSW-1 分离自 Ornithogalum saundersiae，对各种恶性癌细胞具有抗癌活性。 然而，OSW-1 对胶质瘤的影响及其潜在机制仍不清楚。 方法： 网络药理学用于预测 OSW-1 对胶质瘤的抗癌作用的潜在关键靶点和机制。 进行了包括 Cell Counting Kit-8、集落形成和流式细胞术在内的实验，以研究 OSW-1 如何影响胶质瘤细胞的生物学行为 体外. Western印迹用于检测相关蛋白的变化，例如参与细胞周期、细胞凋亡和信号通路的蛋白。 采用裸鼠异种移植模型检测OSW-1抑制胶质瘤细胞 …

OSW-1是20世纪90年代日本科学家从虎眼万年青 (Ornithogalum saundersiae)球茎中分离得到的一种甾体皂苷类物质,结构见图1. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初心，砥砺前 …

Dec 7, 2005 · Using various human cancer and nonmalignant cell lines, we investigated the anticancer activity and selectivity of OSW-1 and its underlying mechanisms of action. OSW-1 exhibited extremely potent cytotoxic activity against cancer cells in vitro.

这一惊人发现，使OSW-1成为21世纪国际医学界抗癌研究领域的最强新秀，与此同时目前我国唯一含有“OSW-1”的抗癌新药——“复方万年青胶囊”，正式被国家食品药品监督管理局（FSDA）批准为国家级的抗癌新药， 批准文号：国药准字B20020717（保健药品）开始广泛应用于临床。 经数十家权威医疗机构临床实验证实：“复方万年青”对肺、肝、胃、肠、食道、胰腺、乳腺、脑及骨、肉瘤等各种 恶性肿瘤 都有一定的疗效。 OSW-1是一种强效的抗癌物质—虎眼万年青皂甙，20 …

OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities. 1 It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with K i values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates. 2 It induces OSBP translocalization f...