The enzyme ornithine decarboxylase (EC 4.1.1.17, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This reaction is the committed step in polyamine synthesis. [1] . In humans, this protein has 461 amino acids and forms a …

2024年5月13日 · What is the ornithine decarboxylase test? The Ornithine Decarboxylase Test is a critical biochemical assay used in microbiology, particularly for differentiating members of the Enterobacteriaceae family.

2024年12月25日 · ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include Bachmann-Bupp Syndrome and Colorectal Cancer. Among its related pathways are Regulation of activated PAK-2p34 …

2022年1月20日 · Arginine, lysine, and ornithine decarboxylase media are used to detect an organism’s ability to decarboxylate or hydrolyze an amino acid, forming an amine that produces an alkaline pH. The basal medium is usually Moeller’s formula and contains meat peptones and beef extract, which supply nitrogenous nutrients to support bacterial growth.

In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis.

2024年8月5日 · The ornithine decarboxylase test is a widely used biochemical assay designed to detect the presence and activity of the enzyme ornithine decarboxylase in bacterial cultures. To initiate the test, a pure bacterial isolate is first inoculated into a medium containing ornithine and a pH indicator, such as bromcresol purple.

Typically, they are composed of a specific amino acid decarboxyl-ase and a membrane exchanger catalysing the entry of the amino acid substrate and the extru-sion of the biogenic amine product. Their com-bined activities contribute to cytosolic pH homeostasis when cells are exposed to acidic en-vironments.

1999年3月3日 · Ornithine decarboxylase (ODC) is a PLP-dependent enzyme that controls a critical step in the biosynthesis of polyamines, small organic polycations whose controlled levels are essential for proper growth.

2015年12月3日 · Ornithine decarboxylase (ODC) is one such downstream effector of c-MYC which regulates polyamine synthesis and thus regulates cell proliferation. ODC is also downstream of RAS which makes it common to two of the important oncogenes involved in MM.

2024年10月27日 · Ornithine decarboxylase (ODC) converts ornithine to putrescine, a precursor in the polyamine biosynthesis pathway. Polyamines, such as putrescine, spermidine, and spermine, are vital for cell proliferation and differentiation.