
OPN5 Gene - GeneCards | OPN5 Protein | OPN5 Antibody
2024年12月25日 · OPN5 (Opsin 5) is a Protein Coding gene. Diseases associated with OPN5 include Cycloplegia. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 11-cis retinal binding.
Violet-light suppression of thermogenesis by opsin 5 ... - Nature
2020年9月2日 · Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light 1, 2. In mice, OPN5 is a known photoreceptor in the retina 3 and skin 4 but is also...
Neuropsin (OPN5) Mediates Local Light-Dependent Induction of …
2019年10月21日 · Organotypic cultures of murine outer ear and vibrissal skin entrain to a light-dark cycle ex vivo, requiring cis-retinal chromophore and Opn5 gene function. Short-wavelength light strongly phase shifts skin circadian rhythms ex vivo via an Opn5-dependent mechanism.
Selective optogenetic control of Gq signaling using human …
2022年4月1日 · Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity...
UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice
The current study clearly determines the absorption maxima of mammalian OPN5 and is the first to report a UV photoreceptor protein in human beings. We also present several lines of evidence suggesting that OPN5 activates a Gi-mediated phototransduction pathway in the …
An opsin 5–dopamine pathway mediates light-dependent ... - Nature
2019年4月1日 · Here, we show that opsin 5 (OPN5; also known as neuropsin)-dependent retinal light responses regulate vascular development in the postnatal eye. In Opn5 -null mice, hyaloid vessels regress...
Opsin 5 is a key regulator of ultraviolet radiation-induced
Objectives: To investigate the function and potential mechanism of opsin 5 (OPN5), a photoreceptor responsive to UVR wavelengths, in melanogenesis in HEMs. Methods: Melanin content in HEMs was determined using the NaOH method, and activity of tyrosinase (TYR) (a key enzyme in melanin synthesis) was determined by the l-DOPA method.
UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice
2011年10月17日 · Here we report that mammalian neuropsin (OPN5) encoded by the Opn5 gene is a UV-sensitive photoreceptor.
UV-sensitive photoreceptor protein OPN5 in humans and mice
OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner. Immuno-blotting analyses of mouse tissue extracts identified the retina, the brain and, unexpectedly, the outer ears as the major sites of OPN5 expression.
Neuropsin (Opn5): a novel opsin identified in mammalian neural …
2003年11月20日 · We report the isolation of a novel mammalian opsin-like gene, Opn5, the first member of a new opsin family. We have determined its gene structure, chromosomal localisation and tissue expression pattern in mice and humans.
- 某些结果已被删除