Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.

2023年4月11日 · Given their importance in imparting oligonucleotides with high target affinity, metabolic stability and favorable pharmacokinetic and -dynamic properties, this article provides a review of these chemistries and their use in nucleic acid therapeutics.

An oligonucleotide is a short chain of nucleotides (nitrogen-containing units linked to a sugar and a phosphate group) that consist of either single- or double-stranded DNA or RNA.

Methodology is now available to determine an accurate, high-pre-cision (i.e., high-resolution) structure of nearly any DNA or RNA double helix of up to 15 to 20 base pairs (bp) via NMR if suffi-cient care and effort are expended (Schmitz and James, 1995).

2023年3月7日 · Given their importance in imparting oligonucleotides with high target affinity, metabolic stability and favorable pharmacokinetic and -dynamic properties, this article provides a review of these chemistries and their use in nucleic acid therapeutics.

2006年8月1日 · We present the crystalline organization of 33 all-AT deoxyoligonucleotide duplexes, studied by x-ray diffraction. Most of them have very similar structures, with Watson-Crick basepairs and a standard average twist close to 36°. The molecules are organized as parallel columns of stacked duplexes in a helical arrangement.

2021年6月24日 · An oligonucleotide is a compound comprised of about three to twenty nucleotides. Each monomeric unit component is comprised of a nucleobase, a pentose moiety, and phosphate group. Oligonucleotides are short DNA or RNA molecules.

Oligonucleotide structure. All oligonucleotide monomers consist of three components: a nucleotide or base (either a purine or a pyrimidine), a pentose five-carbon sugar (either ribose for RNA or deoxyribose for DNA), and a phosphate group.

2024年1月16日 · Comprising short chains of nucleotides, these fundamental structures wield a remarkable influence over the complex dance of genetic information within cells. The three essential components of a...

2020年5月26日 · Oligonucleotides are short DNA or RNA oligomers between 20 and 60 units in length; They can be synthesized or found naturally as single stranded (ss) or double stranded (ds) oligomers. Together with ssDNA/RNA and dsDNA/RNA oligonucleotides also exist as short interfering RNA and larger oligo’s known as aptamers which have 40-60 base pairs.