OCT2 OCT3/4 Oil Red O Olig2 OTP (orthopedia) (pending) P glycoprotein p16 p21 p40 p53 p57 p62 (pending) p63 p120 catenin P504S Pan-TRK PAP PAS PAX2 PAX5 PAX8 PCNA PD-1 PDL1 22C3 PDL1 SP142 PDL1 SP263 (pending) PECAM1 perforin (pending) PGP9.5 (pending) PHLDA1 (pending) phosphohistone H3 Pit1 PLAG1 …

Dec 3, 2024 · EMA-, Olig2+, IDH1 mutation, codeletion of 1p and 19q. Astroblastoma: Astroblastic pseudorosette and IHC profile that resembles ependymoma Located almost exclusively in cerebral hemispheres Stout broad process that is strongly GFAP+ MN1 rearrangement detectable by FISH (Cell 2016;164:1060, Brain Tumor Pathol 2019;36:112) Medulloblastoma:

Generally positive for GFAP, Olig2 (Am J Surg Pathol 2012;36:43, J Neuropathol Exp Neurol 2004;63:499) MAPK pathway activating genetic alterations (e.g. KIAA1549-BRAF fusion) (Nat Genet 2013;45:602) Diffuse glioma: Neoplastic glioma cells infiltrate background brain parenchyma (single cell infiltration, entrapped axons and neurons)

Pineocytoma cells share numerous ultrastructural features with normal mammalian pinealocytes with evidence of neurosensory differentiation (e.g., the presence of vesicle crowned rodlets, cilia [9+0] and fibrous filaments) (Acta Neuropathol 1998;95:532)

Apr 12, 2024 · The tumor shown above was found in the left cerebellar hemisphere of a 45 year old woman. Only rare mitoses are present. It shows diffuse immunostaining for synaptophysin, focal immunostaining for GFAP and is negative for Olig2 and EMA. What is the most likely diagnosis? Cerebellar liponeurocytoma Ependymoma Medulloblastoma Oligodendroglioma

Jun 2, 2023 · Olig2 (J Neurooncol 2017;135:57) GFAP : generally stains only entrapped astrocytes, though may be positive in rare cases ( J Neuropathol Exp Neurol 1997;56:551 , Acta Neuropathol 1996;91:573 ) Electron microscopy description

Jan 17, 2025 · Olig2 (J Neurooncol 2011;104:423) S100 (Am J Surg Pathol 2012;36:43) SOX10 (J Neuropathol Exp Neurol 2016 ...

Immunostains to identify primary site or lineage of metastatic neoplasms (Cancer Cytopathol 2018;126:590, Adv Anat Pathol 2020;27:114, Hum Pathol 2013;44:1):

Jun 23, 2021 · Associated with rare genetic disorder ATDX (ATRX) syndrome, which includes developmental delay, cognitive impairment, various skeletal deformities (PLoS One 2013;8:e85526, Nat Struct Mol Biol 2011;18:769, J Hum Genet 2012;57:73, Eur J …

Oct 14, 2021 · Conventionally, as per current WHO classification, these tumors are termed as choroid plexus papilloma (CPP, WHO grade 1), atypical choroid plexus papilloma (aCPP, WHO grade 2) and choroid plexus carcinoma (CPC, WHO grade 3) (Acta Neuropathol 2016;131:803)