OCT2 OCT3/4 Oil Red O Olig2 OTP (orthopedia) (pending) P glycoprotein p16 p21 p40 p53 p57 p62 (pending) p63 p120 catenin P504S Pan-TRK PAP PAS PAX2 PAX5 PAX8 PCNA PD-1 PDL1 22C3 PDL1 SP142 PDL1 SP263 (pending) PECAM1 perforin (pending) PGP9.5 (pending) PHLDA1 (pending) phosphohistone H3 Pit1 PLAG1 …

2024年9月24日 · Olig2 and S100 positive, monomorphic oligodendroglial-like cells in desmoplastic or myxoid matrix KIAA1549-BRAF fusion, 1p deletion common; 1p19q codeletion and BRAF V600E less common References: Acta Neuropathol 2018;136:239 , …

Generally positive for GFAP, Olig2 (Am J Surg Pathol 2012;36:43, J Neuropathol Exp Neurol 2004;63:499) MAPK pathway activating genetic alterations (e.g. KIAA1549-BRAF fusion) (Nat Genet 2013;45:602) Diffuse glioma: Neoplastic glioma cells infiltrate background brain parenchyma (single cell infiltration, entrapped axons and neurons)

2024年12月3日 · EMA-, Olig2+, IDH1 mutation, codeletion of 1p and 19q. Astroblastoma: Astroblastic pseudorosette and IHC profile that resembles ependymoma Located almost exclusively in cerebral hemispheres Stout broad process that is strongly GFAP+ MN1 rearrangement detectable by FISH (Cell 2016;164:1060, Brain Tumor Pathol 2019;36:112) Medulloblastoma:

2024年10月15日 · A 34 year old man presented with seizures. Magnetic resonance imaging (MRI) reveals a multinodular lesion in the right temporal lobe. Histologic features are shown in the image above. Immunohistochemistry revealed synaptophysin and Olig2 positivity and chromogranin, GFAP and NeuN negativity. What is the most likely diagnosis? Gangliocytoma

2021年12月2日 · Olig2 positive ATRX loss Additional references. Nat Genet 2012;44:251, Neuro Oncol 2021;23:1974. Board ...

2023年10月11日 · Olig2 (J Neurooncol 2017;135:57) GFAP : generally stains only entrapped astrocytes, though may be positive in rare cases ( J Neuropathol Exp Neurol 1997;56:551 , Acta Neuropathol 1996;91:573 ) Electron microscopy description

2024年4月12日 · The tumor shown above was found in the left cerebellar hemisphere of a 45 year old woman. Only rare mitoses are present. It shows diffuse immunostaining for synaptophysin, focal immunostaining for GFAP and is negative for Olig2 and EMA. What is the most likely diagnosis? Cerebellar liponeurocytoma Ependymoma Medulloblastoma Oligodendroglioma

2021年6月23日 · Associated with rare genetic disorder ATDX (ATRX) syndrome, which includes developmental delay, cognitive impairment, various skeletal deformities (PLoS One 2013;8:e85526, Nat Struct Mol Biol 2011;18:769, J Hum Genet 2012;57:73, Eur J …

Chordoid meningioma is a histological subtype of meningioma characterized by cords or trabeculae of epithelioid (or spindle) cells embedded in a mucin rich stroma and resembling chordoma