000632 - B6 ob Strain Details - The Jackson Laboratory
000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. They …
ob/ob mouse - Wikipedia
The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes .
Novel insights into the genetically obese (ob/ob) and ...
2021年6月28日 · Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the ObR [20].
Ob/Ob Mouse - an overview | ScienceDirect Topics
The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice ...
In the present study, we investigated GIP secretion in two mouse models of obesity: High-fat diet-induced obese (DIO) mice and leptin-deficient Lep ob/ob mice. In DIO mice, plasma GIP was increased along with an increase in GIP mRNA expression in the lower small intestine.
The Physiology of Obese-Hyperglycemic Mice [ ob/ob Mice]
This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemic ob/ob mice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.
The leptin-deficient (ob/ob) mouse: a new animal model of ...
This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...