
CD134 - Wikipedia
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively …
The Significance of OX40 and OX40L to T cell Biology and …
This review provides a broad overview of the biology of OX40, and the intracellular signals from OX40, that impact many aspects of immune function, and have promoted OX40 as one of the …
OX40, OX40L and Autoimmunity: a Comprehensive Review
The tumour necrosis factor receptor OX40 (CD134) is activated by its cognate ligand OX40L (CD134L, CD252) and functions as a T cell co-stimulatory molecule. OX40-OX40L interactions …
OX40 ligand - Wikipedia
OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), [1] macrophages, …
Regulation of T Cell Immunity by OX40 and OX40L - Madame …
Reagents that interfere with the binding of OX40 to OX40L have been shown to inhibit T cell responses and pathogenic symptoms in a number of immune based diseases. Conversely …
OX40/OX40 ligand and its role in precision immune oncology
OX40 and its binding ligand OX40L (CD134L; TNFSF4; CD252) are novel immune therapeutic targets that augment the immune response. The gene for OX40 is located on chromosome …
OX40: Structure and function - What questions remain?
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has been validated as a bone …
OX40 (CD134) and OX40 ligand, important immune checkpoints in cancer
So, we reviewed the OX40 and its ligand (OX40L) function in cancer, clinical trials with OX40/OX40L and the correlation between OX40/OX40L and other immune checkpoints to add …
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
2004年6月1日 · In vivo blockade of OX40 signalling specifically suppresses the function of recently activated autoantigen-specific T cells, leading to inhibition of autoimmune disease …
Therapeutic strategies for the costimulatory molecule OX40 in T …
2020年3月1日 · This review discusses the biology of OX40 and OX40L and summarizes the impact of the OX40–OX40L interaction on T cell subsets to provide a comprehensive …