Dec 25, 2024 · OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia and Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia.

Jul 18, 2014 · The OAS1, OAS2 and OAS3 proteins are all active enzymes that can generate 2′–5′-linked oligoadenylates, whereas OASL is devoid of 2′–5′-linked oligoadenylate synthase activity.

Jul 27, 2020 · 2'-5'-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to promote synthesis of 2'-5'-oligoadenylate and thus activation of endoribonuclease L ...

Gene ID: 4938, updated on 8-Feb-2025. This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis.

Feb 25, 2025 · OAS high tumors naturally produce 2-5A that induces antitumor immunity. The 2′,5′-oligoadenylate synthetase (OAS)-RNase L pathway is a classical antiviral innate immune pathway. Upon sensing dsRNA, OAS produces 2′,5′-oligoadenylate (2-5A) as a second messenger to activate RNase L.

Here, we describe a critical antibacterial role for the classic antiviral gene 2′-5′-oligoadenylate synthetase 1 (OAS1). Human OAS1 and its mouse ortholog, Oas1b, are induced by interferon-γ and protect against cytosolic bacterial pathogens such as Francisella novicida and Listeria monocytogenes in vitro and in vivo.

The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially ...

Mar 12, 2024 · Here, we show that human, but not mouse, OAS1 inhibits SARS-CoV-2 replication through its canonical enzyme activity via RNase L. In contrast, both mouse and human OAS1 protect against West Nile virus infection by a mechanism distinct from …

Aug 13, 2024 · The interferon-stimulated gene OAS1 has well-defined antiviral properties. In two recent issues of Immunity, Harioudh et al. describe a non-canonical function of OAS1 that selectively protects the translation of proteins involved …

Sep 25, 2024 · Oligoadenylate synthetase 1 (OAS1) catalyzes the dsRNA-dependent polymerization of ATP to form oligoadenylate, a second messenger of the innate immunity system. This paper reports kinetic and mecha...