Nuclear receptor 4A2 - Wikipedia
The nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein that in humans is encoded by the …
NURR1 in Parkinson disease—from pathogenesis to therapeutic
Oct 15, 2013 · Emerging evidence indicates that impaired NURR1 function might contribute to the pathogenesis of PD: NURR1 and its transcriptional targets are downregulated in midbrain DA …
Decreased NURR1 gene expression in patients with Parkinson’s …
The aims of this study were to determine (1) whether NURR1 gene expression in PBL is specifically reduced in PD as compared with HC and NDC; (2) whether the NURR1 expression …
神经退行性疾病中的核受体｜编译 - 知乎 - 知乎专栏
Nurr1是NR4A家族成员，与II型核受体不同，它可以直接结合DNA，以单体或者 同源二聚体 的形式调节转录，当然也可以与RXR结合成异源二聚体发挥作用。Nurr1在大脑中表达水平很高，使 …
The orphan nuclear receptor Nurr1 is responsive to non ... - Nature
Jul 3, 2020 · Here, we report the discovery of several structurally diverse non-steroidal anti-inflammatory drugs as inverse Nurr1 agonists demonstrating that Nurr1 activity can be …
An optimized Nurr1 agonist provides disease-modifying effects in ...
Jul 18, 2023 · An optimized agonist of Nurr1, 4A7C-301, protects dopamine neurons against environmental and genetic risk factors of Parkinson’s disease (PD) in vitro, and improves both …
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
Jun 27, 2022 · Nuclear receptor-related factor 1 (NURR1), an orphan member of the nuclear receptor superfamily of transcription factors, is a major risk factor in the pathogenesis of PD, …
Molecular Insights into NR4A2(Nurr1): an Emerging Target for ...
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial …
Nurr1的分子结构、分布和生理功能研究进展-期刊-万方数据知识 …
摘要：Nurr1属于孤儿核受体的超家族,人类Nurr1基因位于2号染色体,在中枢多巴胺能系统中高度表达,与中脑多巴胺能神经元的发育、存活密切相关.本文对Nurr 1的分子结构、分布及生理功能 …
Nuclear receptor Nurr1 agonists enhance its dual functions and …
Based on the unique dual role of the nuclear orphan receptor Nurr1 for development and maintenance of mDA neurons and their protection from inflammation-induced death, we …