
The nucleoporin Nup358/RanBP2 promotes nuclear import in a ... - PubMed
The Nup and SUMO E3-ligase Nup358/RanBP2 are the major components of the cytoplasmic filaments of the NPC. In this study, we perform a structure-function analysis of Nup358 and …
Nup358, a nucleoporin, functions as a key determinant of the …
In the present study, we evaluate changes in the expression levels of several nucleoporins and show that the amount of Nup358/RanBP2 within individual NPCs increases during muscle …
Nucleoporin Nup358 drives the differentiation of myeloid-biased …
2024年6月5日 · We report that Nup358, a nucleoporin linked to several myeloid disorders, is required for the developmental progression of early myeloid progenitors.
The Nup358-RanGAP Complex Is Required for Efficient Importin …
2008年2月27日 · Here, we investigate the roles of the Nup358-RanGAP1 complex and of soluble RanGAP1 in nuclear protein transport, combining in vivo and in vitro approaches. Depletion of …
The nuclear pore component Nup358 promotes transportin-dependent ...
2009年4月15日 · Nup358 (also known as RanBP2), a component of the cytoplasmic filaments of the nuclear pore complex, has been implicated in various nucleocytoplasmic transport …
The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a …
In this study, we perform a structure–function analysis of Nup358 and describe its role in nuclear import of specific proteins. In a screen for nuclear proteins that accumulate in the cytoplasm …
Nup358/RanBP2 Attaches to the Nuclear Pore Complex via …
Transmission electron microscopy (TEM) analysis of purified Nup358/RanBP2 revealed a ∼36-nm filamentous structure, and depletion of Nup358 from Xenopus egg extracts caused assembly …
Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide …
Electron microscopy of immunogold-decorated rat liver nuclear envelopes sublocalized the 358-kDa protein at (or near) the tip of the cytoplasmic fibers of the nuclear pore complex (NPC). In …
Nucleoporin Nup358 drives the differentiation of myeloid-biased ...
We report that Nup358, a nucleoporin linked to several myeloid disorders, is required for the developmental progression of early myeloid progenitors.
Nup358 contains a leucine-rich region, four potential Ran binding sites (i.e. Ran binding protein 1 homologous domains) flanked by nucleoporin-characteristic FXFG or FG repeats, eight zinc …
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