The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

2024年12月25日 · NPAS4 (Neuronal PAS Domain Protein 4) is a Protein Coding gene. Diseases associated with NPAS4 include Autism Spectrum Disorder and Inflammatory Bowel Disease 14. Among its related pathways are Transcriptional Regulation by NPAS4 and …

2023年2月15日 · Here we identify an activity-dependent DNA repair mechanism in which a new form of the NuA4–TIP60 chromatin modifier assembles in activated neurons around the inducible, neuronal-specific...

Activated Npas4 regulates the transcription of multiple genes, such as other transcription factors, channel proteins, G-protein signaling molecules, kinases, phosphatases, and genes involved in the modulation of synaptic functions via ubiquitination, trafficking, and receptor endocytosis.

2021年10月20日 · Our data indicate that NPAS4 is necessary for normal transcriptional responses to light in the SCN and critical for photic phase-shifting of circadian behavior. Keywords: NPAS4; light simulation; single-nucleus RNA sequencing; suprachiasmatic nucleus.

Npas4 is involved in activity-dependent synaptic modulation in both excitatory and inhibitory neurons. It regulates the expression of a large number of activity-regulated genes that mediate diverse effects on synapses. Npas4 function is required for memory formation in …

2014年5月22日 · Npas4 is an early-response transcription factor that is enriched in the brain and induced in excitatory neurons specifically upon calcium influx and that has been suggested to regulate excitatory-inhibitory balance within neural circuits (Bloodgood et …

2013年11月6日 · The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes inhibitory synapses on the...

Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A deregulation of the inhibitory-excitatory balance has been associated …

Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A deregulation of the inhibitory-excitatory balance has been ...