The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory …

2024年12月25日 · NPAS4 (Neuronal PAS Domain Protein 4) is a Protein Coding gene. Diseases associated with NPAS4 include Autism Spectrum Disorder and Inflammatory Bowel Disease …

2023年2月15日 · Here we identify an activity-dependent DNA repair mechanism in which a new form of the NuA4–TIP60 chromatin modifier assembles in activated neurons around the …

Activated Npas4 regulates the transcription of multiple genes, such as other transcription factors, channel proteins, G-protein signaling molecules, kinases, phosphatases, and genes involved …

2021年10月20日 · Our data indicate that NPAS4 is necessary for normal transcriptional responses to light in the SCN and critical for photic phase-shifting of circadian behavior. …

Npas4 is involved in activity-dependent synaptic modulation in both excitatory and inhibitory neurons. It regulates the expression of a large number of activity-regulated genes that mediate …

2014年5月22日 · Npas4 is an early-response transcription factor that is enriched in the brain and induced in excitatory neurons specifically upon calcium influx and that has been suggested to …

2013年11月6日 · The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes …

Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A …

Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A …