Novobiocin, also known as albamycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides[1] a member of the class Actinomycetia.

2005年6月13日 · Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity.

2022年8月10日 · Novobiocin is an antibiotic interfering with the unpackaging and repackaging of DNA during DNA replication and the bacterial cell cycle. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity.

2021年7月27日 · The antibiotic novobiocin showed promise as a treatment for cancers with BRCA mutations that have become resistant to PARP inhibitors. It will soon be tested in NCI-supported clinical trials.

2023年2月11日 · Novobiocin is a member of the aminocoumarin antibiotic class produced by Streptomyces niveus Actinobacteria which inhibit the bacterial DNA synthesis process. Novobiocin binds with the GyrB subunit of the DNA gyrase enzyme and inhibits the DNA transcription process.

an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. It should be kept in reserve to be used only when necessary, that is, when resistance to other agents has developed.

An aminocoumarin antibiotic, produced by the actinomycete Streptomyces nivens, with antibacterial property. Novobiocin, as well as other aminocoumarin antibiotics, inhibits bacterial DNA synthesis by targeting at the bacteria DNA gyrase and the related enzyme DNA topoisomerase IV.

novobiocin is an antibiotic used to treat bacterial infections, particularly those caused by certain gram-positive bacteria. Its use has become less common over time due to the development of …

Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides, [1] a member of the order Actinobacteria.

2024年7月5日 · Learn how the Novobiocin test aids in differentiating Staphylococcus species through its mechanism, procedure, and applications in microbiology. Accurate differentiation of bacterial species is crucial for effective diagnosis and treatment in clinical microbiology.