Dec 25, 2024 · NOTCH1 (Notch Receptor 1) is a Protein Coding gene. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Pre-NOTCH Expression and Processing.

The NOTCH1 gene provides instructions for making a protein called Notch1, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks.

Mar 24, 2022 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the development and homeostasis of...

NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).

Mar 10, 2025 · Similarly, Notch1 signalling is involved in neuroectoderm segregation by refining germ layer boundaries during Xenopus laevis gastrulation. Here, a domain of ligand expression is established by a ...

In CLL, NOTCH1 mutations represent a validated prognostic marker and a potential predictive marker for anti-CD20-based therapies, as pathological alterations of the Notch pathway can provide significant growth and survival advantage to neoplastic clone.

Notch1, a member of the Notch family, is implicated in many types of cancer, including breast cancer (especially triple-negative breast cancer), leukemias, brain tumors, and many others. Notch1 is tightly connected to many signaling pathways that are therapeutically involved in …

Mar 3, 2025 · With a novel HCC mouse model and validation in patients with HCC, we demonstrate that NOTCH1 disrupts antitumor immunity specifically in females through a mechanism mediated by sex chromosome genes, which is reversed with CD40 agonism.

Mar 8, 2025 · Title: Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5. Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.

Notch1 expression correlated closely with colorectal cancer differentiation; Notch1 controls early T cell development, in part by regulating the stage- and lineage-specific expression of IL-7Ralpha.