Active Metabolites as Antidepressant Drugs: The Role of Norquetiapine …
Norquetiapine: Active Metabolite of Quetiapine with Antidepressant Activity. The efficacy of quetiapine in treating psychotic disorders, both schizophrenia and mania, as well as mood disorders and anxiety disorders, leads us to view it as a multifunctional psychoactive drug.
A Brief Review of Quetiapine - American Journal of Psychiatry …
2022年12月2日 · Norquetiapine, the active metabolite of quetiapine, is thought to be responsible for the anxiolytic and antidepressant effects of quetiapine through inhibition of the norepinephrine transporter (NET) and serotonin receptor agonism (2).
Quetiapine and its metabolite norquetiapine: translation from
Quetiapine and norquetiapine have multiple in vitro pharmacological actions, and results from preclinical studies suggest that activity at NET and 5‐HT 1A receptors contributes to the antidepressant and anxiolytic effects in patients treated with quetiapine.
Quetiapine - Wikipedia
Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. [11][12] Despite being widely used as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side ...
Active metabolites as antidepressant drugs: the role of norquetiapine …
2013年9月12日 · In this review, we analyze the differential pharmacological aspects between quetiapine and norquetiapine, both from the pharmacokinetic and pharmacodynamic perspectives (affinity for dopaminergic, noradrenegic, and/or serotonergic receptors, etc.), as well as differential neuroprotective role.
Quetiapine and norquetiapine serum concentrations and clinical …
Thereby the antidepressant potential is attributed to the N-demethylated metabolite norquetiapine (NQ). The aim of this cross-sectional analysis was to relate quetiapine (Q) doses to serum concentrations of Q and its active metabolite and clinical effects.
Active Metabolites as Antidepressant Drugs: The Role of Norquetiapine …
2013年9月12日 · In this review, we analyze the differential pharmacological aspects between quetiapine and norquetiapine, both from the pharmacokinetic and pharmacodynamic perspectives (affinity for...
Quetiapine-Induced Hypomania and its Association with …
Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode.
Quetiapine - StatPearls - NCBI Bookshelf
2020年9月8日 · Quetiapine is FDA approved for schizophrenia, acute manic episodes, and adjunctive treatment for major depressive disorder. Quetiapine is also used for several non-FDA-approved indications, such as generalized anxiety disorder. Quetiapine is available both as extended-release (once-daily dosing) or immediate-release (twice-daily dosing) tablets.
Norquetiapine | C17H17N3S | CID 11369918 - PubChem
Norquetiapine | C17H17N3S | CID 11369918 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.