Metastasis suppressor genes (MSGs) inhibit different biological processes during metastatic progression without globally influencing development of the primary tumor. The first MSG, …

2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor …

NM23 is the first discovered metastasis suppressor gene, which does not affect the growth of primary tumor but a powerful inhibitor of metastases of tumors. Altered NM23 expression was …

In this light, further understanding of Lamins/TRF1/2/NM23-H2 or FEN1/NM23-H2 associations might provide meaningful insights into the role of NM23 proteins in telomere biology. Finally, …

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and …

Group I NM23 genes encode enzymes with evolutionarily highly conserved nucleoside diphosphate kinase (NDPK) activity. In this review we summarize how results from NDPKs in …

2020年3月18日 · The metastasis suppressor gene NME/nm23/NDPK was discovered in 1988 by Steeg et al, 1 from the analysis of murine melanoma K-1735 cells based on its differential …

2010年6月6日 · Nm23-H1 enhances the transcriptional activity of a multimerized p53 responsive cis-acting DNA element in human cell lines. Approximately 60% of the genes from the p53 …

The first metastasis suppressor gene confirmed was nm23, also known as NDP kinase. Using in vitro assays, nm23 overexpression resulted in reduced anchorage-independent colonization in …

Nm23-H1 is a metastasis-suppressant gene whose inactivation can affect microtubule polymerization, leading to chromosomal aberrations and aneuploidy formation, thereby …