Dec 25, 2024 · NLRP9 (NLR Family Pyrin Domain Containing 9) is a Protein Coding gene. Diseases associated with NLRP9 include Night Blindness, Congenital Stationary, Type 1D and Petrositis. An important paralog of this gene is NLRP4. As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation.

NLRP9, short for NOD-like receptor family pyrin domain containing 9, is an intracellular protein that is expressed in the ovaries, testes, oocytes, and preimplantation embryos of mammals that is likely involved in reproductive processes.

Recent evidence has suggested that NLRP9 is also capable of initiating inflammasome formation in the intestine to restrict replication and damage brought by rotavirus infection. Here, we highlight the latest progress in characterization of the role of NLRP9 in infectious and inflammatory diseases, as well as the newest crystallographic and ...

NLRP9, one of the less‐characterized NLR members, has been shown to initiate inflammasome activation in host defence against rotavirus infection. This review highlights the latest progress in characterization of the role of NLRP9 in infectious and ...

Dec 6, 2020 · Here, we highlight the latest progress in characterization of the role of NLRP9 in infectious and inflammatory diseases, as well as the newest crystallographic and biochemical studies on NLRP9. Finally, we discuss some important questions remained to be answered regarding the molecular and cellular mechanisms governing NLRP9's function in ...

Jun 21, 2017 · Our data show that, via RNA helicase Dhx9, Nlrp9b recognizes short double-stranded RNA stretches and forms inflammasome complexes with the adaptor proteins Asc and caspase-1 to promote the...

最近的证据表明，nlrp9 还能够在肠道中启动炎性体形成，以限制轮状病毒感染带来的复制和损害。 这里，我们重点介绍了 NLRP9 在传染病和炎症性疾病中作用的最新进展，以及对 NLRP9 的最新晶体学和生化研究。

Gene ID: 338321, updated on 8-Feb-2025. The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD).

Oct 1, 2023 · Nucleotide-binding oligomerization domain (NOD)-like receptors with a pyrin domain (PYD)-containing protein 9 (NLRP9) was the first nucleotide-binding region receptor (NLR) proposed to be expressed and function only in the reproductive system.

Dec 6, 2020 · NLRP9, one of the less‐characterized NLR members, has been shown to initiate inflammasome activation in host defence against rotavirus infection. This review highlights the latest progress in chara...