Dec 25, 2024 · NLRP6 (NLR Family Pyrin Domain Containing 6) is a Protein Coding gene. Diseases associated with NLRP6 include Colitis and Chemical Colitis. Gene Ontology (GO) annotations related to this gene include vasopressin receptor activity. An important paralog of this gene is NLRP3.

Apr 27, 2021 · NLRP6 exhibits diverse functions in the regulation of host response against pathogenic infections and gut inflammation. Emerging evidence suggests context-reliant inflammasome-dependent and -independent functions.

Jan 27, 2020 · In this review, we summarize the recent advancements in knowledge of the signaling mechanisms and structure of the Nlrp6 inflammasome and discuss the relevance of NLRP6 to human disease.

NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols the cytosolic compartment of cells to detect pathogen- and damage-associated molecular patterns.

Nov 11, 2021 · Nlrp6-deficient or Nlrp6 K350-354A mutant mice show reduced inflammasome activation upon mouse hepatitis virus or rotavirus infection, and in steady state stimulated by intestinal microbiota, implicating NLRP6 LLPS in anti-microbial immunity.

In this review, we summarize recent understandings on the assembly, activation and regulation patterns of the NLRP6 inflammasome, as well as its diverse impacts on tissue homeostasis and disease in multiple organs. Keywords: caspase, inflammasome, ...

In this review, we summarize the recent advancements in knowledge of the signaling mechanisms and structure of the Nlrp6 inflammasome and discuss the relevance of NLRP6 to human disease.

NLRP6 is a newly characterized member of this family that inhibits NF-κB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6. 1.

Jul 1, 2012 · Here we show that Nlrp6 -deficient mice are highly resistant to infection with the bacterial pathogens Listeria monocytogenes, Salmonella typhimurium and Escherichia coli.

NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, regulates inflammation and host defense against microorganisms.