The sensor NLRP12 is associated with infectious and inflammatory diseases, but its activating triggers and roles in cell death and inflammation remain unclear. Here, we discovered that NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF.

Jun 12, 2023 · 在一项新的研究中，来自美国圣犹达儿童研究医院的研究人员发现在应对血红素以及伴随的其他细胞损伤或感染时，一种先天 免疫 模式识别受体---NLRP12---是负责诱导炎症细胞死亡和病理的关键分子。 这一发现为预防某些疾病的发病率提供了一种新的潜在药物靶标。 相关研究结果于2023年6月1日在线发表在Cell期刊上，论文标题为“NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs”。 许多感染性和炎症性疾病，包 …

Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.

NLRP12 (NOD-like receptors family pyrin domain containing 12)是固有免疫系统模式识别受体NOD样受体 (NOD-like receptors，NLR)家族的主要成员之一，是胞浆内抵御外来病原体入侵的重要蛋白。 在某些情况下，NLRP12能被激活并与下游效应蛋白组装成炎症小体，参与病原清除；另一方面，NLRP12是NLR家族中少有的具有抗炎作用的分子。 该文将对NLRP12的结构与组织分布、功能及其在疾病发生发展中的作用进行综述。 引用本文: 钟林庆, 宋红梅. NLRP12及其在疾 …

Jun 1, 2023 · Here, we discovered that NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18.

Oct 5, 2023 · NLRP12 is involved in multiple disease processes, including formation of inflammasomes and regulation of both canonical and noncanonical inflammatory signaling pathways. NLRP12 and pathogenic infections are closely linked, and alterations in NLRP12 expression and activity are associated with inflammatory diseases.

Dec 25, 2024 · NLRP12 (NLR Family Pyrin Domain Containing 12) is a Protein Coding gene. Diseases associated with NLRP12 include Familial Cold Autoinflammatory Syndrome 2 and Familial Cold Autoinflammatory Syndrome 3. Among its related pathways are SARS-CoV-2 Infection and Infectious disease.

NLRP12 is a member of the NLR family that contains an N-terminal pyrin domain, a central nucleotide-binding domain, and a C-terminal leucine-rich repeat. It has been shown to play a role in forming an inflammasome in response to specific infections, and it can also function as a regulator of inflammatory signaling.

nlrp12是最近鉴定出的nlr家族的成员，在一些病人体内能够检测到nlrp12的突变，这些突变造成了病人周期性的发热以及特征性皮炎。 之前的体外实验认为NLRP12是TLR信号通路的负向调节分子，最近的一些研究将NLRP12与炎症反应的负向调控也联系起来。

At least 20 variants (also known as mutations) in the NLRP12 gene have been found to cause familial cold autoinflammatory syndrome type 2. This condition causes episodes of fever, skin rash, and joint pain, often in response to cold temperatures.