Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or …

2024年12月25日 · NLRP12 (NLR Family Pyrin Domain Containing 12) is a Protein Coding gene. Diseases associated with NLRP12 include Familial Cold Autoinflammatory Syndrome 2 and …

2023年10月5日 · NLRP12 and pathogenic infections are closely linked, and alterations in NLRP12 expression and activity are associated with inflammatory diseases. In this review, we begin …

During Yersinia pestis or Plasmodium chabaudi, infection, NLRP12 induces the release of the inflammasome-dependent cytokines IL-1β and IL-18. These NLRP12-dependent cytokines …

NLRP12 is a member of the NLR family that contains an N-terminal pyrin domain, a central nucleotide-binding domain, and a C-terminal leucine-rich repeat. It has been shown to play a …

2023年6月1日 · NLRP12 is an immune sensor that activates cell death and inflammation when it senses heme and pathogen-associated molecular danger signals indicative of hemolytic …

At least 20 variants (also known as mutations) in the NLRP12 gene have been found to cause familial cold autoinflammatory syndrome type 2. This condition causes episodes of fever, skin …

2020年7月28日 · Patients with NLRP12 variants develop a rare autosomal dominant condition known as familial cold-induced autoinflammatory syndrome (FCAS2, OMIM #611762) that has …

NLRP12, first described about 10 years ago, is a cytoplasmic sensor to be categorized as a negative regulator of inflammation. A recent study has also shown that NLRP12 can form an …

2024年1月23日 · We first investigated whether NLRP12 directly interacted with NLRP3 by coexpressing human NLRP3 with human full-length NLRP12, a mutant NLRP12 without its …