Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.

2024年12月25日 · NLRP12 (NLR Family Pyrin Domain Containing 12) is a Protein Coding gene. Diseases associated with NLRP12 include Familial Cold Autoinflammatory Syndrome 2 and Familial Cold Autoinflammatory Syndrome 3. Among its related pathways are SARS-CoV-2 Infection and Infectious disease.

2023年10月5日 · NLRP12 and pathogenic infections are closely linked, and alterations in NLRP12 expression and activity are associated with inflammatory diseases. In this review, we begin with a summary of the mechanisms of negative regulation by NLRP12.

During Yersinia pestis or Plasmodium chabaudi, infection, NLRP12 induces the release of the inflammasome-dependent cytokines IL-1β and IL-18. These NLRP12-dependent cytokines confer protection against severe infections caused by these pathogens.

NLRP12 is a member of the NLR family that contains an N-terminal pyrin domain, a central nucleotide-binding domain, and a C-terminal leucine-rich repeat. It has been shown to play a role in forming an inflammasome in response to specific infections, and it can also function as a regulator of inflammatory signaling.

2023年6月1日 · NLRP12 is an immune sensor that activates cell death and inflammation when it senses heme and pathogen-associated molecular danger signals indicative of hemolytic diseases.

At least 20 variants (also known as mutations) in the NLRP12 gene have been found to cause familial cold autoinflammatory syndrome type 2. This condition causes episodes of fever, skin rash, and joint pain, often in response to cold temperatures.

2020年7月28日 · Patients with NLRP12 variants develop a rare autosomal dominant condition known as familial cold-induced autoinflammatory syndrome (FCAS2, OMIM #611762) that has been related to several different clinical manifestations including …

NLRP12, first described about 10 years ago, is a cytoplasmic sensor to be categorized as a negative regulator of inflammation. A recent study has also shown that NLRP12 can form an inflammasome during infection with Yersinia pestis, although this study needs to be substantiated by independent groups .

2024年1月23日 · We first investigated whether NLRP12 directly interacted with NLRP3 by coexpressing human NLRP3 with human full-length NLRP12, a mutant NLRP12 without its LRR domain (N12ΔLRR, representing the NLRP12 patient mutation V635ThrfsX12), or the Walker AB mutant NLRP12 and then immunoprecipitating NLRP3.