2024年12月25日 · NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Diseases associated with NLRC3 include Cinca Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. An important paralog of this gene is NLRP12.

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. [5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 …

2016年12月12日 · Here we show that mice lacking NLRC3 are hyper-susceptible to colitis and colorectal tumorigenesis. The effect of NLRC3 is most dominant in enterocytes, in which it suppresses activation of the...

2022年10月20日 · NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells.

Here we found that the nucleotide-binding, leucine-rich repeat containing protein, NLRC3, reduced STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, and impeded STING-TBK1 interaction and downstream type I interferon production.

2014年3月20日 · Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses.

2025年2月8日 · NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma. [Knockdown of NLRC3 promotes proliferation and invasion of human colon cancer cells]. NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6/JAK2/STAT3 pathway activation.

NLRC3, a negative regulator, exhibits considerable potential in the realm of lung cancer immunotherapy by virtue of its profound impact on the immune response intensity, primarily through its regulatory effects on the cGAS-STING pathway.

2022年10月19日 · NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells.

2024年1月3日 · In this study, we find that Nlrc3, a nucleotide-binding domain leucine-rich repeat containing family gene, is highly expressed in hematopoietic differentiation stages in vivo and vitro and is...