One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on …

Dec 25, 2024 · Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific …

Sep 19, 2017 · Natural killer (NK) cells are the first line of defense against pathogens of the immune system and also play an important role in resistance against HIV. The activating …

Mar 10, 2023 · It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this …

Jan 26, 2021 · NKG2C is an activating NK cell receptor encoded by the KLRC2 gene, which binds to HLA-E on infected cells leading to NK cell activation. Heterozygous or homozygous KLRC2 …

We report for the first time that NKG2C, a receptor traditionally associated with immune cells, is also expressed by GBM tumor cells, especially at the invasive front. The presence of NKG2C …

Aug 1, 2015 · The NKG2C+ NK cell subset has been proposed to play a role in viral infection, especially in cytomegalovirus (CMV), and has been shown to expand and enhance their IFN-γ …

Sep 17, 2024 · In-depth single-cell RNA-seq unveiled a unique transcriptional signature in these NK cells linked to increased cell metabolism, migration, chemotaxis, effector functions, …

Mar 22, 2019 · In the present study we have evaluated the molecular basis for the impaired NK cell inhibition by these peptides and determined the cell surface stability of individual p:HLA-E …

Apr 21, 2011 · We therefore report that the NKG2A inhibitory receptor plays a central inhibitory role, providing a regulatory feedback mechanism for controlling the activating NKG2C …