One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies.

2024年12月25日 · Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity.

2017年9月19日 · Natural killer (NK) cells are the first line of defense against pathogens of the immune system and also play an important role in resistance against HIV. The activating receptor NKG2C and the inhibitory receptor NKG2A co-modulate the function of NK cells by recognizing the same ligand, HLA-E.

2023年3月10日 · It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection.

2021年1月26日 · NKG2C is an activating NK cell receptor encoded by the KLRC2 gene, which binds to HLA-E on infected cells leading to NK cell activation. Heterozygous or homozygous KLRC2 deletion...

We report for the first time that NKG2C, a receptor traditionally associated with immune cells, is also expressed by GBM tumor cells, especially at the invasive front. The presence of NKG2C on tumor cells correlates with an altered immune profile and increased responsiveness to immune checkpoint inhibition.

2015年8月1日 · The NKG2C+ NK cell subset has been proposed to play a role in viral infection, especially in cytomegalovirus (CMV), and has been shown to expand and enhance their IFN-γ producing capacity following CMV infection and reactivation in humans and upon culture with CMV-infected fibroblasts [10], [11], [12], [13], [14], [15].

2024年9月17日 · In-depth single-cell RNA-seq unveiled a unique transcriptional signature in these NK cells linked to increased cell metabolism, migration, chemotaxis, effector functions, cytokine secretion, and antiviral response.

2019年3月22日 · In the present study we have evaluated the molecular basis for the impaired NK cell inhibition by these peptides and determined the cell surface stability of individual p:HLA-E complexes and their binding efficiency to soluble NKG2A/CD94 or NKG2C/CD94 receptors.

2011年4月21日 · We therefore report that the NKG2A inhibitory receptor plays a central inhibitory role, providing a regulatory feedback mechanism for controlling the activating NKG2C receptor, reminiscent of the activation-dependent expression of CTLA-4 on T lymphocytes that counteracts CD28-mediated costimulation. 8 These findings are consistent with the ...