2024年12月25日 · NEUROG1 (Neurogenin 1) is a Protein Coding gene. Diseases associated with NEUROG1 include Cranial Dysinnervation Disorder, Congenital, With Absent Corneal Reflex And Developmental Delay and Cerebellar Liponeurocytoma. Among its related pathways are Neural crest differentiation and Transcriptional Regulatory Network in Embryonic Stem Cell.

Neurogenin 1 (Ngn1) is a Class-A basic-helix-loop-helix (bHLH) transcription factor that acts as a regulator for neuronal differentiation, and acts by binding to enhancer regulatory elements on genes that encode transcriptional regulators of neurogenesis.

2025年2月8日 · genetic analysis has identified Ngn1 as a gene required in basal progenitors to activate an OSN differentiation program, and force dividing progenitors out of the cell exit. Ngn1 antagonizes differentiation of dI3 interneuron subtype by repressing dI3 progenitor development; neurogenin1 regulates neuroD2 expression during mouse brain development

在这里我们报告说Neurogenin1（Ngn1），一种在发育过程中指导祖细胞神经元分化的神经元基因的表达足以将MSC的中胚层细胞命运转变为神经元。 表达Ngn1的MSC表达神经元特异性蛋白，包括NeuroD以及亲代MSC中不存在的电压门控Ca2 +和Na +通道。

The NEUROGENINS (NGNs) are neural-specific basic helix-loop-helix (bHLH) transcription factors. Mouse embryos lacking ngn1 fail to generate the proximal subset of cranial sensory neurons. ngn1 is required for the activation of a cascade of downstream bHLH factors, including NeuroD, MATH3, and NSCL1. …

1998年3月1日 · Mouse embryos lacking ngn1 fail to generate the proximal subset of cranial sensory neurons. ngn1 is required for the activation of a cascade of downstream bHLH factors, including NeuroD, MATH3, and NSCL1. ngn1 is expressed …

2024年2月22日 · Ngn1具有决定神经元特性和亚型的功能，其生成的数量与特性在时间与空间上的顺序受限于增殖的神经祖细胞。 Ngn1可强烈诱导与神经细胞迁移相关的基因，激活神经发生的程序，包括细胞表面变化，诱导基因参与细胞迁移、转录因子和细胞周期调控因子。

2001年2月9日 · We generated adenoviruses expressing either the Myc-tagged wild-type neurogenin (Myc-Ngn1) or the Myc-Ngn1(nm)/control, which expresses six repeats of the Myc tag but no Ngn1 protein. Western analysis indicates that Ngn1 inhibits the expression of a glial marker, GFAP, and induces the expression of neuronal-specific β-tubulin (TuJ1 antigen ...

Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including animal organ morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in neuronal cell body. Predicted to be part of chromatin.

Neurogenin1(Ngn1)是碱性螺旋-环-螺旋(basic helix-loop-helix,bHLH)家族成员。在神经系统发育过程中,Ngn1在神经前体细胞(neuronal precursors)中被诱导表达。Ngn1能促进神经细胞分化,并抑制神经胶质细胞分化,是一种神经细胞分化过程中关键的调控蛋白。