Neurogenin-3 (NGN3) is a protein that in humans is encoded by the Neurog3 gene. Neurogenin-3 is a pro-endocrine transcription factor that is a member of the basic helix-loop-helix (bHLH) transcription factor and has a primary function of activating gene transcription in endocrine progenitor cells. [ 5 ]

Dec 25, 2024 · NEUROG3 (Neurogenin 3) is a Protein Coding gene. Diseases associated with NEUROG3 include Diarrhea 4, Malabsorptive, Congenital and Diarrhea 5, With Tufting Enteropathy, Congenital. Among its related pathways are Regulation of beta-cell development and Nervous system development.

Nov 2, 2017 · Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) are transcription factors critical for beta cell development and maturation. NEUROG3 is expressed in endocrine progenitor cells and controls islet differentiation and regeneration.

Neurogenin3 (NEUROG3) is required for endocrine lineages formation of the pancreas and intestine. Patients with NEUROG3 mutations are born with congenital malabsorptive diarrhea due to complete loss of enteroendocrine cells, whereas endocrine pancreas development varies in an allele-specific manner.

Feb 8, 2025 · NEUROG3 deficiency produces a rare clinical syndrome characterised by severe malabsorptive diarrhoea from early life and mild diabetes with a variable age of onset. Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.

Jul 20, 2006 · Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine-cell development in the pancreas and intestine. The NEUROG3 gene (NEUROG3) is therefore a...

NEUROG3. Patients with homozygous NEUROG3 mutations most often present with infancy-onset diabetes and malabsorptive diarrhea.

Aug 5, 2019 · Neurogenin3 (NEUROG3) is required for endocrine lineage formation of the pancreas and intestine. Patients with NEUROG3 mutations are born with congenital malabsorptive diarrhea due to complete loss of enteroendocrine cells, whereas endocrine pancreas development varies in an allele-specific manner. …

Mar 6, 2025 · Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm ( Gradwohl et al., 2000 ).

Nov 11, 2014 · Gain- and loss-of-function manipulations in the chick and mouse embryo show that Neurog3 switches ventral progenitors from a serotonergic to V3 differentiation program by repressing Ascl1 in spinal p3 progenitors through a mechanism dependent on Hes proteins.