2024年12月25日 · NEUROG2 (Neurogenin 2) is a Protein Coding gene. Diseases associated with NEUROG2 include Neuropathy, Hereditary Sensory And Autonomic, Type Iii and Pervasive Developmental Disorder. Among its related pathways are DYRK1A involvement regarding cell proliferation in brain development and Dopaminergic neurogenesis.

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene. [5] Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix transcription factor genes that play an important role in neurogenesis. [6] It has been found to reprogram astrocytes to glutamatergic neurons when expressed. [7]

2025年1月4日 · Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. Perrin FE, et al. PLoS One, 2010 Dec 30. PMID 21209909, Free PMC Article. Neurogenin 2 enhances the generation of patient-specific induced neuronal cells. Zhao P, et al. Brain Res, 2015 Jul 30.

2021年3月1日 · In the midbrain, Neurog2-induced neuronal cells (Neurog2-iNs) exhibit neuronal morphology, mature electrophysiological properties, glutamatergic identity (about 60%), and synapse-like...

2024年1月11日 · Mining single cell data from cerebral organoids and human fetal cortices, we found that NEUROG2 expression is enriched in basal neural progenitor cells. To identify and purify NEUROG2-expressing cells and trace their short-term lineage, we engineered two NEUROG2-mCherry knock-in

2019年5月13日 · Using direct neuronal programming of embryonic stem cells, we found that two main vertebrate proneural factors, Ascl1 and neurogenin 2 (Neurog2), induce different neuronal fates by binding to...

2021年3月1日 · In the spinal cord, astrocytes from both the intact and lesioned sources could be converted into functional neurons with ectopic expression of Neurog2 alone. Notably, further evidence from our study also proves that Neurog2-iNs in the intact spinal cord are capable of responding to diverse afferent inputs from dorsal root ganglion (DRG).

By comparing the activities of transcriptional activator (Neurog2-VP16) and repressor (Neurog2-EnR) fusions to wild-type Neurog2, we first demonstrate that Neurog2 functions as an activator to both extinguish Pax6 expression in radial glial cells and initiate Tbr2 expression in intermediate neuronal progenitors.

2025年1月15日 · Using ChIP-qPCR, gene silencing and overexpression studies in COs, we show NEUROG2 is necessary and sufficient to directly transactivate known target genes (NEUROD1, EOMES, RND2). To identify new targets, we engineered NEUROG2-mCherry knock …

2022年2月7日 · In addition, we functionally demonstrate a new role for Neurog2 in directly mediating enhancer activity, DNA demethylation, increasing chromatin accessibility and facilitating chromatin looping...