Neurexins (NRXN) are a family of presynaptic cell adhesion proteins that have roles in connecting neurons at the synapse. [1] . They are located mostly on the presynaptic membrane and contain a single transmembrane domain.

2021年1月8日 · In this Review, we first summarize insights into Neurexin function obtained from various model organisms. We then discuss the mechanisms and logic of the cell type-specific regulation of...

Neurexins act predominantly at the presynaptic terminal in neurons and play essential roles in neurotransmission and differentiation of synapses. Some of these functions require the formation of trans-synaptic complexes with postsynaptic proteins …

Neurexins are one type of synaptic cell adhesion molecule that have, recently, gained more pathological interest. Variants in both neurexins and their common binding partners, neuroligins, have been associated with several neuropsychiatric disorders.

Neurexins are type I transmembrane proteins with a single path transmembrane helix (TM) that separates amino-terminal extracellular from cytosolic intracellular domains.

Neurexin is a type I transmembrane protein that plays a role in neurotransmitter release. It is encoded by three genes and can generate multiple isoforms through alternative splicing. You might find these chapters and articles relevant to this topic.

Neurexins are presynaptic adhesion molecules expressed from three genes (NRXN1 - 3 in humans, Nrxn1 - 3 in mice). All neurexin genes contain independent promoters for two principal forms (a- and b-neurexins), with b-neurexins being generally less abundant than a-neurexins 1-3.

In this Review, we first summarize insights into Neurexin function obtained from various model organisms. We then discuss the mechanisms and logic of the cell type-specific regulation of Neurexin isoforms, in particular at the level of alternative mRNA splicing.

Neurexins are central synaptic organizers implicated in neuropsychiatric diseases. Together with their partners, neurexins form transsynaptic bridges that span the synaptic cleft. A striking constellation of structural features enables neurexins to …

In this review, we first summarize insights into Neurexin function obtained from various model organisms. We then discuss mechanisms and logic of the cell type-specific regulation of Neurexin isoforms, in particular at the level of alternative mRNA splicing.