Nerve growth factor - Wikipedia
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described.
Nerve Growth Factor: A Focus on Neuroscience and Therapy
Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons.
Nerve Growth Factor: Early Studies and Recent Clinical Trials
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system.
Nerve growth factor: from the early discoveries to the potential ...
The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its ...
Nerve Growth Factor - an overview | ScienceDirect Topics
Nerve growth factor (NGF) is the prototype of a family of structurally related neurotrophic factors, known as neurotrophins. In the peripheral nervous system, NGF supports the development and maintenance of sympathetic and neural crest-derived sensory neurons ( Levi Montalcini and Calissano, 1986 ).
Nerve growth factor: structure and function - PubMed
Nerve growth factor (NGF), the best characterized member of the neurotrophin family, sends its survival signals through activation of TrkA and can induce cell death by binding to p75NTR. Recent domain deletion and mutagenesis studies have identified the membrane-proximal domain of the Trks as necessary and sufficient for ligand binding.
The History of Nerve Growth Factor: From Molecule to Drug
2024年5月29日 · Nerve growth factor (NGF), the first neurotrophin to be discovered, has a long and eventful research journey with a series of turning points, setbacks, and achievements.
Nerve Growth Factor - an overview | ScienceDirect Topics
NGF is a growth factor that promotes the survival and proliferation of neurons, including the peripheral sensory and sympathetic neurons [72]. There are two structurally different types of receptors identified for NGF, the high affinity receptor tyrosine kinase A (TrkA) and the low-affinity neurotrophin receptor p75 [73,74].
Nerve growth factor: role in growth, differentiation and …
Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer cells.
Nerve Growth Factor: Early Studies and Recent Clinical Trials
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system.