The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor …

2024年12月25日 · NCOA2 (Nuclear Receptor Coactivator 2) is a Protein Coding gene. Diseases associated with NCOA2 include Rhabdomyosarcoma 2 and Aneurysmal Bone Cysts. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Bile acid and bile salt metabolism.

2016年10月3日 · Title: Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression. Our results demonstrate uterine tumor resembling ovarian sex-cord tumors are defined by recurrent fusions involving NCOA2 or NCOA3

Conclusions: NCOA2 has great potential to serve as a novel biomarker that can predict prognosis in ccRCC and may become a new therapeutic target in patients with late-stage ccRCC. Keywords: NCOA2, biomarker, prognosis, renal cell carcinoma, DNA methylation, immune infiltration.

2020年6月23日 · The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes.

2023年10月4日 · Forced expression of PGC-1α in Ncoa2fl/fl/CD4Cre CD8+ T cells restored mitochondrial function, T-cell activation, IFNγ production, and antitumor immunity. This work informs the development of Ncoa2-based therapies that modulate CD8+ T cell-mediated antitumor immune responses.

2014年10月8日 · Here we determined that nuclear receptor coactivator 2 (NCoA2, also known as SRC-2), which is frequently amplified or overexpressed in patients with metastatic PCa, mediates development of CRPC.

2019年3月18日 · As a member of the p160 steroid receptor coactivator (SRC) family, nuclear receptor coactivator 2 (NCOA2) is known to play essential roles in many physiological and pathological processes, including development, endocrine regulation, and tumorigenesis. However, the biological function of NCOA2 in breast cancer is not fully understood.

2020年6月3日 · Knockdown of NCOA2 Can Suppress the Proliferation of Gastric Cancer Cells. The cancer MKN-28sh and BGC-823sh cell clusters with knockdown NCOA2 genes were significantly smaller than those of MKN-28nc and BGC-823nc cells.

2003年5月1日 · ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells. 7: 36309571: 2022: A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a. 2: 34624096: 2022: