Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene. [5][6][7][8] Na v 1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels.

KO studies have confirmed a role for both Nav1.7 and Nav1.8 in the pathophysiology of inflammatory pain with these animals displaying reduced/attenuated inflammatory pain behaviours. A better understanding regarding the contributions of these channels in pathological pain is beginning to develop.

2024年12月1日 · In this review, we summarize the latest developments in Na v 1.8-selective inhibitors, focusing on the druggable sites and mechanisms that confer subtype specificity.

2023年8月2日 · We describe the preclinical characterization of VX-548, an oral, highly selective inhibitor of Na V 1.8, and we report the results of two phase 2 trials evaluating the efficacy and safety of...

2025年1月21日 · Voltage-gated sodium (Nav) channels in the peripheral nervous system-Nav1.7, Nav1.8, and Nav1.9-play crucial roles in pain signaling. Among these, Nav1.8 has shown promise due to its rapid recovery from inactivation and role in repetitive firing, with recent clinical studies providing proof-of-principal that block of Nav1.8 can reduce pain in ...

Growing evidence indicates that the voltage-gated sodium channel Na v 1.8 plays a critical role in transmission of pain-related signals throughout the body. For that reason, this channel appears to have strong potential to help develop novel, more selective, safer, and efficacious analgesics.

2021年3月29日 · Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-subtypes Nav1.7, Nav1.8 and Nav1.9 are important in the peripheral signalling of pain.

Nav1.8 is a voltage-gated sodium channel (VGSC) that is important for neuronal excitability in nociception. Alterations in Nav1.8 sodium current in sensory neurons affect normal pain-signaling and underlie the pathophysiology of pain states, such …

The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron–specific (SNS) due to prominent expression in primary sensory neurons including dorsal root ganglion (DRG) neurons.

2016年2月2日 · The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron-specific (SNS) due to prominent expression in primary sensory neurons including dorsal root ganglion (DRG) neurons. Early studies on rodent NaV1.8 demonstrated depolarized voltage dependence of channel inactivatio …