
Nav1.8 - Wikipedia
Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene. [5][6][7][8] Na v 1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels.
Nav1.7 and Nav1.8: Role in the pathophysiology of pain - PMC
KO studies have confirmed a role for both Nav1.7 and Nav1.8 in the pathophysiology of inflammatory pain with these animals displaying reduced/attenuated inflammatory pain …
Drug discovery targeting Nav1.8: Structural insights and …
2024年12月1日 · In this review, we summarize the latest developments in Na v 1.8-selective inhibitors, focusing on the druggable sites and mechanisms that confer subtype specificity.
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain | NEJM
2023年8月2日 · We describe the preclinical characterization of VX-548, an oral, highly selective inhibitor of Na V 1.8, and we report the results of two phase 2 trials evaluating the efficacy and …
Nav1.8, an analgesic target for nonpsychotomimetic ... - PubMed
2025年1月21日 · Voltage-gated sodium (Nav) channels in the peripheral nervous system-Nav1.7, Nav1.8, and Nav1.9-play crucial roles in pain signaling. Among these, Nav1.8 has shown …
Insights into the voltage-gated sodium channel, NaV1.8, and its …
Growing evidence indicates that the voltage-gated sodium channel Na v 1.8 plays a critical role in transmission of pain-related signals throughout the body. For that reason, this channel …
The physiological function of different voltage-gated sodium ... - Nature
2021年3月29日 · Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-subtypes Nav1.7, Nav1.8 and Nav1.9 are important in the peripheral signalling of pain.
Transiently Nav1.8-expressing neurons are capable of sensing …
Nav1.8 is a voltage-gated sodium channel (VGSC) that is important for neuronal excitability in nociception. Alterations in Nav1.8 sodium current in sensory neurons affect normal pain …
Sodium channel Nav1.8 | Neurology
The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron–specific (SNS) due to prominent expression in primary sensory neurons including …
Sodium channel Nav1.8: Emerging links to human disease
2016年2月2日 · The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron-specific (SNS) due to prominent expression in primary sensory neurons …