Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family [7] of intracellular transcription factors. [6] [8] NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. [9] Nuclear receptor 4A1 plays a key role in mediating inflammatory responses in …

2024年12月25日 · NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding gene. Diseases associated with NR4A1 include Pseudohypoaldosteronism and 46,Xy Sex Reversal 2. Among its related pathways are Gene expression (Transcription) and …

进一步的t细胞过继实验证明敲除nr4a1赋予cd8 + t细胞更强的效应功能，更好地抵御肿瘤以及病毒的耗竭微环境的能力(图2)。 图2为nr4a1 表达水平与cd8 + t细胞的肿瘤杀伤能力成负相关

NR4A1 binding also promotes acetylation of histone 3 at lysine 27 (H3K27ac), leading to activation of tolerance-related genes. This study thus identifies NR4A1 as a key general regulator in the induction of T cell dysfunction, and a potential target for tumour immunotherapy.

2025年3月4日 · NR4A1 may serve as a novel therapeutic target for managing thrombosis-based cardiovascular diseases, especially with hypercholesterolemia. We provide the first evidence that nuclear receptor NR4A1 negatively regulates platelet activation and thrombus formation.

2019年2月27日 · This study thus identifies NR4A1 as a key general regulator in the induction of T cell dysfunction, and a potential target for tumour immunotherapy.

2014年6月11日 · 核受体 nr4a1是核受体 nr4a家族中的重要一员，可通过对靶细胞基因转录的调节，参与细胞的增殖、凋亡调控，在肿瘤发生、血管重塑以及类固醇合成等重要生命活动过程中发挥重要作用，其功能受到磷酸化、蛋白质相互作用等多种途径的调控。

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1. Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.

核受体亚家族 4 A 组成员 1： 该基因编码类固醇-甲状腺激素-类视黄醇受体超家族的成员。表达由人淋巴细胞中的植物血凝素和停滞的成纤维细胞的血清刺激诱导。编码的蛋白质充当核转录因子。蛋白质从细胞核转移到线粒体会诱导细胞凋亡。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供 ...

2024年6月25日 · Hao et al. further demonstrate that NR4A1 regulates Tpex cell development and maintenance in the tumor microenvironment. NR4A1 inhibits effector cytokine production and fosters accumulation of Tpex cells by directly stimulating Tpex-related genes while repressing genes associated with terminal exhaustion.