Dec 25, 2024 · NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. Diseases associated with NR3C1 include Glucocorticoid Resistance, Generalized and Primary Hyperaldosteronism. Among its related pathways are Gene expression (Transcription) and Infectious disease.

Feb 9, 2025 · It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants …

Gene ID: 2908, updated on 9-Feb-2025. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors.

May 20, 2024 · Clinical resource with information about NR3C1, Genome-wide meta-analysis identifies new susceptibility loci for migraine., Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs., Glucocorticoid resistance, and available tests.

Jan 19, 2023 · This study aimed to investigate the relationship between methylation at the glucocorticoid receptor gene (NR3C1) and PTSD treatment success of evidence-based psychotherapy.

Aug 1, 2015 · The NR3C1 gene codes for the glucocorticoid receptor, a key element involved in several steps of HPA axis modulation. In this review, we gather existing evidence linking NR3C1 methylation pattern with either ELS or psychopathology.

The NR3C1 gene codes for the glucocorticoid receptor, a key element involved in several steps of HPA axis modulation. In this review, we gather existing evidence linking NR3C1 methylation pattern with either ELS or psychopathology.

Apr 5, 2023 · NR3C1-encoding glucocorticoid receptors have dual roles as RNA-binding protein and transcription factor. Recent studies revealed that NR3C1 might play an important role in the pathogenesis of PTSD (Post-traumatic stress disorder).

Bray and Cotton (2003) reported that a total of 15 missense, 3 nonsense, 3 frameshift, 1 splice site, and 2 alternatively spliced mutations had been reported in the NR3C1 gene to be associated with glucocorticoid resistance; 16 polymorphisms had also been reported.

Chromosome 5: 142,657,496-142,815,077 reverse strand. This gene has 17 transcripts (splice variants), 11 paralogues and is associated with 3 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000113580;r=5:142657496-142815077;time=1741523433318.318" failed to load.