NPM1 - Wikipedia
NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It …
NPM1 Gene - GeneCards | NPM Protein | NPM Antibody
2024年12月25日 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Acute Myeloid Leukaemia With Myelodysplasia-Related Features and …
Significance of NPM1 Gene Mutations in AML - PMC - PubMed …
The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal …
Functions of the native NPM1 protein and its leukemic mutant
2024年12月17日 · Thanks to its property to act as histone chaperone and to shuttle between the nucleus and cytoplasm, the NPM1 protein is involved in multiple cellular function that are here …
NPM1 -mutated acute myeloid leukemia: from bench to bedside
2020年10月8日 · NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the …
How I diagnose and treat NPM1 -mutated AML - American …
2021年2月4日 · Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia (AML).
Current status and future perspectives in targeted therapy of NPM1 ...
2022年8月25日 · NPM1 mutations are the most common genetic alteration in acute myeloid leukemia (AML), detected in about 30–35% of adult AML and more than 50% of AML with …
NPM1-fusion proteins promote myeloid leukemogenesis through …
2024年10月23日 · Nucleophosmin (NPM1) is a nucleolar protein and one of the most frequently mutated genes in acute myeloid leukemia (AML). In addition to the commonly detected …
核磷蛋白 1（NPM1）基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质参与多种细胞过程，包括中心体复制、蛋白质伴侣和细胞增殖。 编码的磷蛋白在核仁、细胞核和细胞质之间穿梭，陪伴核糖体蛋白和核心组蛋白从细胞核到细胞质。 还已 …
JHO：曹雪涛团队揭示癌症免疫治疗新靶点——NPM1_澎湃号·湃 …
2024年11月25日 · 核磷蛋白（npm1）是最丰富的核仁蛋白之一，npm1基因的突变与多种血液系统恶性肿瘤相关，包括急性髓系白血病（aml）。 有研究表明，NPM1通过促进细胞增殖和抑制 …