
NPC1L1 - Wikipedia
Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells [5] as well as in hepatocytes. [6] Specifically, it appears to bind to a critical mediator of …
NPC1L1 Gene - GeneCards | NPCL1 Protein | NPCL1 Antibody
2024年12月25日 · NPC1L1 (NPC1 Like Intracellular Cholesterol Transporter 1) is a Protein Coding gene. Diseases associated with NPC1L1 include Low Density Lipoprotein Cholesterol …
Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and …
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes. It functions as a …
NPC1L1 and Cholesterol Transport - PMC - PubMed Central (PMC)
NPC1L1 protein possesses multiple conserved domains, including a SSD that is found in many other proteins involved in cholesterol metabolism and regulation. NPC1L1 mediates intestinal …
Structural insights into the mechanism of human NPC1L1
2021年7月16日 · Niemann-Pick C1-like 1 (NPC1L1) protein plays a central role in the intestinal cholesterol absorption and is the target of a drug, ezetimibe, which inhibits NPC1L1 to reduce …
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic ...
NPC1L1 is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that is widely used in treating hypercholesterolemia. Recent findings suggest that NPC1L1 deficiency …
Genetic demonstration of intestinal NPC1L1 as a major …
We developed a mouse model that lacks endogenous (NPC1L1) and LDL receptor (LDLR) (DKO), but transgenically expresses human NPC1L1 in gastrointestinal tract only (DKO/L1 IntOnly …
NPC1L1 NPC1 like intracellular cholesterol transporter 1
2025年2月8日 · Common single nucleotide polymorphisms at the NPC1L1 gene locus significantly predict cardiovascular risk in coronary patients. Genetic variation in the cholesterol transporter …
Bile acids-mediated intracellular cholesterol transport ... - Nature
2023年10月13日 · Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, …
The structure and function of Niemann-Pick C1-like 1 protein
In 2004, NPC1L1 was identified to be essential for intestinal cholesterol absorption, a process that is sensitive to a cholesterol absorption inhibitor ezetimibe. This review summarizes recent …
NPC1L1 NPC1 like intracellular cholesterol transporter 1 [ (human)]
2025年2月8日 · Hepatic NPC1L1 exacerbates diet-induced steatosis, which was accompanied by decreased hepatic ability of VLDL-TG secretion. The obtained results provide a deeper …
Potential function of hepatic Niemann–Pick C1-like 1: cholesterol ...
2025年3月7日 · Abstract. Niemann–Pick C1-like 1 (NPC1L1) is distributed in the human liver and intestine but only slightly expressed in the mouse liver. While it is well established that …
Structural insights into the mechanism of human NPC1L1 …
Here, we present cryo–electron microscopy structures of human NPC1L1 in apo state, cholesterol-enriched state, and ezetimibe-bound state to reveal molecular details of NPC1L1 …
Structures of dimeric human NPC1L1 provide insight into ... - PubMed
2021年8月18日 · Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). The drug ezetimibe …
Structures of dimeric human NPC1L1 provide insight into …
The cryo-EM structures of human NPC1L1 reveal a dimeric state mediating cholesterol and vitamin E uptake. Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal …
NPC1L1 - an overview | ScienceDirect Topics
Pathways and transporter molecules regulating intestinal cholesterol absorption and transport. Lumenal cholesterol and other sterols (including plant and other sterols) are transported …
Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter
Niemann-Pick C1 Like 1 (NPC1L1) has been identified and characterized as an essential protein in the intestinal cholesterol absorption process. NPC1L1 localizes to the brush border …
NPC1L1 and cholesterol transport - ScienceDirect
2010年7月2日 · NPC1L1 protein possesses multiple conserved domains, including a SSD that is found in many other proteins involved in cholesterol metabolism and regulation. NPC1L1 …
The role of NPC1L1 in cancer - PMC - PubMed Central (PMC)
A crucial part in the intestinal absorption of cholesterol is played by Niemann–Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small intestine and …
NPC1L1 — Вікіпедія
NPC1L1 (англ. NPC1 like intracellular cholesterol transporter 1) – білок, який кодується однойменним геном, розташованим у людей на 7-й хромосомі. [4]
NPC1L1 and cholesterol transport - PubMed
2010年7月2日 · The hepatic function of NPC1L1 may be to limit excessive biliary cholesterol loss. NPC1L1-dependent sterol uptake seems to be a clathrin-mediated endocytic process and is …
The role of NPC1L1 in cancer - PubMed
2022年8月10日 · A crucial part in the intestinal absorption of cholesterol is played by Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small …