Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells [5] as well as in hepatocytes. [6] Specifically, it appears to bind to a critical mediator of …

2024年12月25日 · NPC1L1 (NPC1 Like Intracellular Cholesterol Transporter 1) is a Protein Coding gene. Diseases associated with NPC1L1 include Low Density Lipoprotein Cholesterol …

Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes. It functions as a …

NPC1L1 protein possesses multiple conserved domains, including a SSD that is found in many other proteins involved in cholesterol metabolism and regulation. NPC1L1 mediates intestinal …

2021年7月16日 · Niemann-Pick C1-like 1 (NPC1L1) protein plays a central role in the intestinal cholesterol absorption and is the target of a drug, ezetimibe, which inhibits NPC1L1 to reduce …

NPC1L1 is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that is widely used in treating hypercholesterolemia. Recent findings suggest that NPC1L1 deficiency …

We developed a mouse model that lacks endogenous (NPC1L1) and LDL receptor (LDLR) (DKO), but transgenically expresses human NPC1L1 in gastrointestinal tract only (DKO/L1 IntOnly …

2025年2月8日 · Common single nucleotide polymorphisms at the NPC1L1 gene locus significantly predict cardiovascular risk in coronary patients. Genetic variation in the cholesterol transporter …

2023年10月13日 · Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, …

In 2004, NPC1L1 was identified to be essential for intestinal cholesterol absorption, a process that is sensitive to a cholesterol absorption inhibitor ezetimibe. This review summarizes recent …

2025年2月8日 · Hepatic NPC1L1 exacerbates diet-induced steatosis, which was accompanied by decreased hepatic ability of VLDL-TG secretion. The obtained results provide a deeper …

2025年3月7日 · Abstract. Niemann–Pick C1-like 1 (NPC1L1) is distributed in the human liver and intestine but only slightly expressed in the mouse liver. While it is well established that …

Here, we present cryo–electron microscopy structures of human NPC1L1 in apo state, cholesterol-enriched state, and ezetimibe-bound state to reveal molecular details of NPC1L1 …

2021年8月18日 · Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). The drug ezetimibe …

The cryo-EM structures of human NPC1L1 reveal a dimeric state mediating cholesterol and vitamin E uptake. Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal …

Pathways and transporter molecules regulating intestinal cholesterol absorption and transport. Lumenal cholesterol and other sterols (including plant and other sterols) are transported …

Niemann-Pick C1 Like 1 (NPC1L1) has been identified and characterized as an essential protein in the intestinal cholesterol absorption process. NPC1L1 localizes to the brush border …

2010年7月2日 · NPC1L1 protein possesses multiple conserved domains, including a SSD that is found in many other proteins involved in cholesterol metabolism and regulation. NPC1L1 …

A crucial part in the intestinal absorption of cholesterol is played by Niemann–Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small intestine and …

NPC1L1 (англ. NPC1 like intracellular cholesterol transporter 1) – білок, який кодується однойменним геном, розташованим у людей на 7-й хромосомі. [4]

2010年7月2日 · The hepatic function of NPC1L1 may be to limit excessive biliary cholesterol loss. NPC1L1-dependent sterol uptake seems to be a clathrin-mediated endocytic process and is …

2022年8月10日 · A crucial part in the intestinal absorption of cholesterol is played by Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small …