
NOD2 - Wikipedia
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16.
NOD2 gene - MedlinePlus
The NOD2 gene (previously known as CARD15) provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as bacteria and viruses.
NOD2, an intracellular innate immune sensor involved in host …
2011年7月13日 · Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for small peptides derived from the bacterial cell wall component, peptidoglycan.
NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
Here we discuss recent developments about the mechanisms by which NOD1 and NOD2 are activated by bacterial ligands, the regulation of their signaling pathways, and their role in host defense and inflammatory disease.
Nod2: The intestinal gate keeper - PMC - PubMed Central (PMC)
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response.
NOD2 Gene - GeneCards | NOD2 Protein | NOD2 Antibody
2024年12月25日 · NOD2 (Nucleotide Binding Oligomerization Domain Containing 2) is a Protein Coding gene. Diseases associated with NOD2 include Blau Syndrome and Inflammatory Bowel Disease 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.
Clinical Disease States Related to Mutations of the NOD2 Gene: A …
Nucleotide-binding oligomerization domain-containing protein-2 (NOD2) is a protein encoded by the NOD2 gene that plays an important role in the immune system. Mutations in the NOD2 gene have been linked to several autoimmune and immunodeficiency diseases [ 1 ].
NOD2 - an overview | ScienceDirect Topics
NOD2 is a cytosolic sensor that recognizes muramyl dipeptide (MDP), a peptidoglycan derived from bacterial cell walls, and genetic variants have been linked to Crohn's disease [188,189]. NOD2 is also linked to inflammasome activation, in concert with NLRP1 and NLRP3 [190,191].
NOD2 and inflammation: current insights - PMC - PubMed Central …
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Nod2: The intestinal gate keeper | PLOS Pathogens
2017年3月2日 · Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan (PGN)-conserved motifs in cytosol and stimulates host immune response.