NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1 gene. [5] [6] It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the NOD-like receptor family of pattern recognition receptors.

核苷酸结合寡聚化结构域(nod)和富含亮氨酸重复序列的家族蛋白x1(nlrx1)是nod样受体(nlr)家族的一员，是免疫系统的重要调节因子。研究表明，nlrx1能够调控nf-κb信号和Ⅰ型干扰素生成，调节活性氧的产生，参与自噬、细胞死亡和固有免疫反应，并影响jnk和mapk途径。

Dec 25, 2024 · NLRX1 (NLR Family Member X1) is a Protein Coding gene. Diseases associated with NLRX1 include Long Qt Syndrome and Histiocytic Sarcoma. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and DDX58/IFIH1-mediated induction of interferon-alpha/beta. An important paralog of this gene is NLRP14.

Mar 27, 2023 · The mitochondrial sensor NLRX1. NLRX1 is ubiquitously expressed in mammals. It has a central NACHT and LRR domain and a unique N-terminus, which functions as a mitochondrial targeting...

Dec 1, 2022 · NLRX1 is currently the only NLR known to be located in mitochondria through a mechanism presumed to be associated with its special N-terminal domain, and it establishes a novel connection between mitochondrial function and disease pathophysiology. NLRX1 functions as a negative regulator of the body's inflammatory response.

NLRX1 is a member of this NLR sub-group and acts as an enigmatic regulator of immune system function. NLRX1 has been shown to negatively regulate type-I interferon, attenuate pro-inflammatory NF-κB signaling, promote reactive oxygen species production, and modulate autophagy, cell death, and proliferation.

Jan 16, 2008 · Here we describe human NLRX1, a highly conserved nucleotide-binding domain (NBD)- and leucine-rich-repeat (LRR)-containing family member (known as NLR) that localizes to the mitochondrial outer...

Aug 11, 2023 · nlrx1 是 nod 样受体 (nlr) 家族的成员，它代表一种独特的模式识别分子 (prm)，因为它在静息条件下定位于线粒体基质。 在过去的十五年里，NLRX1 被认为可以调节多种细胞过程，包括抗病毒免疫、细胞凋亡、活性氧 (ROS) 生成和线粒体代谢。

NLRX1 is a member of this NLR sub-group and acts as an enigmatic regulator of immune system function. NLRX1 has been shown to negatively regulate type-I interferon, attenuate pro-inflammatory NF-κB signaling, promote reactive oxygen species production, and modulate autophagy, cell death, and proliferation.

Feb 9, 2025 · NLRX1 regulates TNF-alpha-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells. NLRX1 was downregulated in tumor tissue compared with adjacent normal liver tissue.