Dec 25, 2024 · NLRP7 (NLR Family Pyrin Domain Containing 7) is a Protein Coding gene. Diseases associated with NLRP7 include Hydatidiform Mole, Recurrent, 1 and Gestational Trophoblastic Neoplasm. Among its related pathways are Toll-Like receptor Signaling Pathways and Nucleotide-binding oligomerization domain (NOD) pathway.

In this review, we focus on NLRP7 and discuss the current evidence of its role in inflammasome regulation and its implication in human reproductive diseases. Keywords: inflammasome; inflammation; innate receptors; macrophage; reproductive immunology.

NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene. [3][4][5] NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family.

In this review, we focus on NLRP7 and discuss the current evidence of its role in inflammasome regulation and its implication in human reproductive diseases. Keywords: inflammasome, inflammation, innate receptors, macrophage, reproductive immunology.

Jan 26, 2025 · NLRP7 dysfunctions affect embryonic development and lead to Hydatidiform Moles, but the underlying mechanisms remain largely elusive. Here, we show that NLRP7 knockout affects the genetic...

Feb 8, 2025 · NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest. NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway. Novo pathogenic variations of NLRP7 increasing the risk of gestational trophoblastic neoplasia.

The NLRP7 gene provides instructions for making a protein whose role is not known. The NLRP7 protein is thought to be involved in regulating gene activity (expression) through a phenomenon known as genomic imprinting.

Aug 19, 2020 · Mutations in the maternal-effect gene NLRP7 are the major cause of familial recurrent complete HM. Here, we established an in vitro model of HM using patient-specific induced pluripotent stem...

Here, we demonstrate that peripheral blood mononuclear cells from patients with NLRP7 mutations and rare variants secrete low levels of IL-1β and TNF in response to LPS.

May 6, 2023 · NLRP7 is a component of human subcortical maternal complex. NLRP7 variants lead to poor quality of oocytes and early embryo development arrest. This study provides a new genetic marker for clinical early embryo arrest patients.