Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. [5] .

Dec 25, 2024 · NFE2L2 (NFE2 Like BZIP Transcription Factor 2) is a Protein Coding gene. Diseases associated with NFE2L2 include Immunodeficiency, Developmental Delay, And …

Our findings revealed the possible role of NFE2L2 across cancers, suggesting that NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in many cancers, …

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key transcription factor in the cellular defense against oxidative stress, playing a crucial role in …

NFE2L2 modulates autophagy gene expression and suggests a new strategy to combat proteinopathies. Identify an Nrf2-mediated 17-gene signature, which reflects a cluster of gene …

Oct 10, 2017 · Somatic mutations of NFE2L2 leading to NRF2 accumulation promote cell survival and drug resistance in cancer cells. Here we show that the same mutations as inborn de novo …

NFE2L2 is a master regulator of antioxidant/detoxifying system. GABPA controls the transcription of many mitochondrial/metabolic genes. NFE2L2, GABPA and PGC-1alpha are implicated in …

NFE2L2 mutation causes several types of cancer such as esophageal squamous cell carcinoma, lung squamous cell carcinoma (LUSC), head and neck cancer, prostate cancer, hepatocellular …

Nov 24, 2015 · Nuclear factor, erythroid 2-like 2 (NFE2L2), a transcription factor also known as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant …

Oct 9, 2020 · The present study revealed that NFE2L2 was abnormally expressed and significantly correlated with mismatch repair (MMR) gene mutation levels and DNA …