2024年12月25日 · NFE2L2 (NFE2 Like BZIP Transcription Factor 2) is a Protein Coding gene. Diseases associated with NFE2L2 include Immunodeficiency, Developmental Delay, And Hypohomocysteinemia and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Nuclear events mediated by NFE2L2 and Infectious disease.

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. [5] .

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key transcription factor in the cellular defense against oxidative stress, playing a crucial role in cancer cell survival and resistance to therapies.

Our findings revealed the possible role of NFE2L2 across cancers, suggesting that NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in many cancers, especially in LGG.

NFE2L2 modulates autophagy gene expression and suggests a new strategy to combat proteinopathies. Identify an Nrf2-mediated 17-gene signature, which reflects a cluster of gene ontology terms highly related to tuberculosis physiology.

2017年10月10日 · Somatic mutations of NFE2L2 leading to NRF2 accumulation promote cell survival and drug resistance in cancer cells. Here we show that the same mutations as inborn de novo mutations cause an early...

2015年11月24日 · Nuclear factor, erythroid 2-like 2 (NFE2L2), a transcription factor also known as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant and stress ...

NFE2L2 is a master regulator of antioxidant/detoxifying system. GABPA controls the transcription of many mitochondrial/metabolic genes. NFE2L2, GABPA and PGC-1alpha are implicated in the same patho-physiological processes. Rui Kang, ... Daolin Tang.

The elimination of ROS is largely accomplished by induction of NFE2L2 (NRF2) targets and since NFE2 shows very similar binding specificity, it can compete with NFE2L2 for induction of proteins that eliminate ROS.

2020年10月9日 · The present study revealed that NFE2L2 was abnormally expressed and significantly correlated with mismatch repair (MMR) gene mutation levels and DNA methyltransferase expression in human pan-cancer.