2017年7月14日 · NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a...

Therefore, the nature of the signals elicited by the respective death inducers determines whether NF-kappaB induction leads to apoptosis or survival, suggesting that the manipulation of NF-kappaB activity may provide a new approach to adjuvant therapy in cancer treatment.

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival.

2006年1月6日 · Here we review evidence of roles for NF- κ B in the regulation of developmental and synaptic plasticity, and cell survival in physiological and pathological settings. Signaling pathways...

2020年3月30日 · NF-κB is well known for providing cancer cells with a survival advantage by upregulating antiapoptotic genes. There is a reciprocal crosstalk between NF-κB and autophagy in cancer, where it...

With so many years of in‐depth research on NF‐κB, people have realized that the NF‐κB signaling pathway plays an important role in inflammation, immunity, cell survival and proliferation. This review summarizes the relevant knowledge of the NF‐κB signaling pathway, inflammation, and …

2024年7月11日 · We identified p53-mediated apoptotic cell death as a major contributor to dopamine neuron loss and uncovered a causal link of tumor necrosis factor alpha (TNF-α)-nuclear factor κB (NF-κB) signaling in limiting cell survival.

The genes induced and signaling pathways influenced by NF-κB play a fundamental role in B cells’ development, differentiation, and survival. It is important to understand the mechanisms that govern target-gene selection by NF-κB, the crosstalk between multiple receptors that can activate NF-κB and the crosstalk between the canonical and ...

2016年11月1日 · TG2/NF-kB signaling axis is critical for MCL survival. Many cancer cells constitutively express NF-kB components and show elevated levels of phosphorylated STAT3 (p-STAT3) due to the upregulation of cytokines such as IL-6 or IL-10 .

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB activation depends on phosphorylation-induced proteosomal ...