NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently …

Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell …

NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is a protein involved in the regulation of cell growth, viability and development. [2] It is found ubiquitously …

2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein …

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication.

NEDD8 is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin RING ligases. Many non-cullin neddylation targets have been proposed in recent years. …

2024年12月25日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease . Among its …

2021年10月12日 · Here, the authors identify similarities and differences of ubiquitin and NEDD8 phosphorylation, showing that phosphorylated NEDD8 has a distinct interactome and …

2018年10月22日 · Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/ubiquitin conjugates.

NEDD8 /RUB1 (NEDD8) is an 8 kDa protein that is closely related to ubiquitin. Just like ubiquitin, NEDD8 can be conjugated to proteins (neddylation). Unlike ubiquitin, however, NEDD8 does …